The Inuit cancer pattern--the influence of migration

International Journal of Cancer. Journal International Du Cancer
Trine BoysenMads Melbye

Abstract

The Inuit cancer pattern is characterized by high frequencies of Epstein-Barr Virus (EBV)-associated carcinomas of the nasopharynx and salivary glands. The reasons are unknown, but genetic and environmental factors are believed to be involved. Using data from the well-defined Inuit population in Greenland we investigated whether migration to Denmark influenced their risk of cancer. Greenland is part of the Danish Kingdom, and population-based registries cover both countries. Using rates for Denmark as reference, sex-specific standardized incidence ratios (SIR) were calculated for Inuit who never lived in Denmark and for those who at least once were registered with a Danish address. During 1973-2003, we observed 3,567 cancers in a cohort of 77,888 persons. Of these, 862 among 26,214 Inuit ever living in Denmark, and 2,705 among 51,674 nonmigrating Inuit. High SIRs for cancers of the nasopharynx [31.7 (CI 22.0-45.5)] and salivary glands [3.1 (CI 1.4-6.9)] observed among Inuit migrating to Denmark were comparable to those observed among Inuit never living in Denmark. Significant higher risk of cancer of the bladder, breast, prostate gland, skin, brain and stomach was observed among Inuit following migration to Denmark. The SIR was...Continue Reading

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Citations

Apr 22, 2009·International Journal of Epidemiology·Richard G Stevens
Jun 6, 2012·International Journal of Circumpolar Health·Gisèle M CarrièreNeil Goedhuis
Aug 5, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Dayalu S L NaikSuresh Hedau
Mar 22, 2014·Social Psychiatry and Psychiatric Epidemiology·Carsten Rygaard HjorthøjMerete Nordentoft
Jun 9, 2009·Familial Cancer·Theresa Larriba HarboeMarie Luise Bisgaard
Feb 12, 2014·Acta Oncologica·Bente B SanderElsebeth Lynge
Sep 2, 2008·The Lancet Oncology·Jeppe T Friborg, Mads Melbye
Jan 17, 2017·Ecology Letters·Michael E Hochberg, Robert J Noble
Feb 4, 2009·International Journal of Circumpolar Health·UNKNOWN Circumpolar Inuit Cancer Review Working GroupCarmina Ng
Feb 3, 2021·Surgical Pathology Clinics·Lester D R Thompson, Rumeal D Whaley

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