The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis

Cerebrovascular Diseases
Libor VítekJirí Spácil

Abstract

Serum bilirubin is negatively associated with the development of coronary heart disease. In the present study, we have focused on the analysis of intima-media thickness (IMT) of the common carotid artery in hyper- and normobilirubinemic subjects. The study was performed on 111 men without manifested atherosclerosis. In all subjects, complete biochemical tests were determined along with the examination of IMT by carotid ultrasound. The mean IMT in hyperbilirubinemic subjects as compared with controls was substantially lower (p=0.017), and hyperbilirubinemic men also had very low age-adjusted prevalence odds ratios for having IMT above the 50th percentiles of controls, even after adjustment for selected vascular risk factors (p=0.034). In the present study, we demonstrate the inverse relationship between serum bilirubin and IMT in healthy men.

References

Feb 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·P N HopkinsR R Williams
Oct 1, 1996·Journal of Cardiovascular Risk·G T KoC S Cockram
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·N IshizakaH Hashimoto
May 18, 2001·The American Journal of Cardiology·L DjousséR C Ellison
Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·David E BarananoSolomon H Snyder
Apr 24, 2003·Experimental Biology and Medicine·Ladislav Novotný, Libor Vítek

❮ Previous
Next ❯

Citations

Jun 22, 2011·Rheumatology International·Zaixing YangRenqian Zhong
Jan 17, 2008·European Journal of Human Genetics : EJHG·François M PetitPhilippe Labrune
Dec 27, 2007·Journal of Medicinal Food·Mark F McCarty
May 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Petronella E DeetmanRobin P F Dullaart
Oct 5, 2013·BMC Endocrine Disorders·Maya TanakaRyoichi Takayanagi
Jun 28, 2011·Journal of Lipid Research·Pernette R W de Sauvage NoltingUNKNOWN ExPRESS study group
Aug 8, 2013·PloS One·Barbara AndriaFulvio Calise
May 21, 2014·Pathology, Research and Practice·Mustafa CengizSeren Ozenirler
Sep 29, 2007·Canadian Journal of Physiology and Pharmacology·Lucie MuchovaDavid K Stevenson
Jan 5, 2011·Indian Journal of Pediatrics·Vesna Stojanović, Tamara Vukavić
Mar 5, 2011·Indian Journal of Pediatrics·Viroj Wiwanitkit
Feb 19, 2015·Nutrients·Lynnda J N van Tienhoven-Wind, Robin P F Dullaart
Apr 30, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Bosa Mirjanic-AzaricDarko Cerne
Apr 12, 2014·Annals of Medicine·Seung Joo KangPeter Kruzliak
Sep 17, 2013·Journal of Diabetes·Syeda Sadia NajamGuang Ning
Nov 29, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y LiR-t Wang
Jul 2, 2015·Clinical Biochemistry·Robin P F DullaartJoop D Lefrandt
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Libor VítekTokio Yamaguchi
Oct 24, 2013·Journal of Gastroenterology and Hepatology·Amit Goel, Rakesh Aggarwal
Jul 1, 2010·Pediatric Blood & Cancer·Shelley E CraryGeorge R Buchanan
May 1, 2012·Alimentary Pharmacology & Therapeutics·M HjelkremS A Harrison
Feb 17, 2015·Journal of Cellular and Molecular Medicine·Lucie MuchovaLibor Vitek
Sep 27, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robin P F DullaartRindert de Vries
Mar 22, 2016·European Journal of Clinical Investigation·Jorien Werumeus BuningRobin P F Dullaart
Sep 3, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yun LuoYun Xu
Apr 26, 2014·Atherosclerosis·Muhei TanakaNaoto Nakamura
Apr 30, 2017·Journal of the American Heart Association·Dongdong WangAtanas G Atanasov
Sep 15, 2007·Pediatric Blood & Cancer·Sarah B TroendleGeorge R Buchanan
Dec 28, 2018·Clinical Pharmacology and Therapeutics·Libor VitekClaudio Tiribelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.