The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials

Trials
Gemma L ClaytonHayley E Jones

Abstract

When designing and analysing clinical trials, using previous relevant information, perhaps in the form of evidence syntheses, can reduce research waste. We conducted the INVEST (INVestigating the use of Evidence Synthesis in the design and analysis of clinical Trials) survey to summarise the current use of evidence synthesis in trial design and analysis, to capture opinions of trialists and methodologists on such use, and to understand any barriers. Our sampling frame was all delegates attending the International Clinical Trials Methodology Conference in November 2015. Respondents were asked to indicate (1) their views on the use of evidence synthesis in trial design and analysis, (2) their own use during the past 10 years and (3) the three greatest barriers to use in practice. Of approximately 638 attendees of the conference, 106 (17%) completed the survey, half of whom were statisticians. Support was generally high for using a description of previous evidence, a systematic review or a meta-analysis in trial design. Generally, respondents did not seem to be using evidence syntheses as often as they felt they should. For example, only 50% (42/84 relevant respondents) had used a meta-analysis to inform whether a trial is needed ...Continue Reading

References

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Citations

Sep 7, 2018·Statistics in Medicine·Hayley E JonesNicky J Welton
Aug 31, 2018·Trials·Reynaldo MartinaUNKNOWN GetReal Workpackage 1
Oct 30, 2020·BMC Medical Ethics·Daria Kim, Joerg Hasford
Jun 7, 2021·Journal of Clinical Epidemiology·B Nussbaumer-StreitUNKNOWN working group 3 in the EVBRES COST Action (https://evbres.eu)

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Software Mentioned

INVEST

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