The investigation and management of severe hyperandrogenism pre- and postmenopause: non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Suresh VaikkakaraRichard Quinton

Abstract

An androgen-secreting tumor needs to be excluded in any woman with severe hyperandrogenism. We sought to characterize patients with biochemical hyperandrogenism in respect of tumor versus non-tumor etiologies, explore possible links between non-tumor hyperandrogenism and metabolic syndrome, and ascertain whether metformin therapy can elicit diagnostic reductions in serum testosterone (T). Seven-year retrospective study of all women referred to a university hospital endocrinology service with baseline T >4.0 nmol/l. Dataset comprised age, menopausal status, body mass index (BMI), presence/absence of hypertension, diabetes, acanthosis or dyslipidemia, along with changes in BMI and serum T following intervention with metformin, oophorectomy or dexamethasone. Non-tumor hyperandrogenism was defined by normalization of serum T or >40% reduction from baseline. Four out of 18 cases had adrenal carcinoma that was clinically obvious at initial presentation (one virilized, three Cushingoid). The remaining 14 were characterized by metabolic syndrome (BMI: 39.9 +/- 8.1 kg/m(2)), serum T of 6.14 +/- 1.6 nmol/l, and nadir serum T following intervention of 2.2 +/- 1.04 nmol/l. Diagnostic reductions in serum T occurred in 11/12 patients treated...Continue Reading

References

Jan 1, 1985·AJR. American Journal of Roentgenology·S HussainH L Abrams
Oct 13, 1994·The New England Journal of Medicine·J DerksenC J van de Velde
Feb 1, 1997·Clinical Endocrinology·R S Rittmaster
Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·R B Barnes
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
May 10, 2003·Obstetrics and Gynecology·Ricardo Azziz
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Gregory A KaltsasG Michael Besser
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Lyndal HarborneJane Norman
May 10, 2006·Journal of Endocrinological Investigation·P A Essah, J E Nestler
May 24, 2007·The Journal of Clinical Endocrinology and Metabolism·Robin H FogleRichard J Paulson

❮ Previous
Next ❯

Citations

Jan 13, 2015·Case Reports in Endocrinology·Murat AtmacaYasin Sezgin
Sep 8, 2011·European Journal of Endocrinology·Julie SarfatiUNKNOWN Study Group Hyperandrogenism in Postmenopausal Women
Oct 27, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shalini PatlollaSravani Chiri
Dec 17, 2020·Journal of the Endocrine Society·Eng-Loon Tng, Jeanne May May Tan
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Adnin Zaman, Micol S Rothman
Mar 5, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eng-Loon Tng, Jeanne May-May Tan
May 15, 2021·Climacteric : the Journal of the International Menopause Society·T Yoldemir

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
Teresa MontoyaJuana Olivar
Zhonghua nan ke xue = National journal of andrology
Guo-Hong WangZhong-Shu Zhang
© 2021 Meta ULC. All rights reserved