The Investigation and Treatment of Diabetic Gastroparesis

Clinical Therapeutics
Mohit KumarShazli Azmi

Abstract

This review provides an update on the investigations and treatment options for gastroparesis. A comprehensive literature search of Medline, PubMed, Embase and OVID was conducted which included all systematic reviews and research articles that focused on the diagnosis, investigations and management diabetic gastroparesis. Dietary modifications and pharmacologic treatment with prokinetics to increase gastric motility form the mainstay of treatment. However, the use of prokinetics is limited by adverse effects and serious adverse effects, leaving metoclopramide as the only drug approved by the US Food and Drug Administration for the treatment of gastroparesis. Newer therapies, including motilin receptor agonists, ghrelin receptor agonists, and neurokinin receptor antagonists, are currently being investigated. Transpyloric stenting, gastric electrical stimulation, and gastric per-oral endoscopic myotomy provide mechanical options for intervention, and surgical interventions in severe intractable gastroparesis include laparoscopic pyloroplasty or gastrectomy. Advances to better understand the pathophysiology and management of diabetic gastroparesis have been limited, especially with discordance between symptoms and severity of delay...Continue Reading

Citations

Sep 12, 2018·Cold Spring Harbor Perspectives in Medicine·Bruno BonazSonia Pellissier
Jul 18, 2019·Internal Medicine Journal·Kieran J Longley, Vincent Ho
Sep 1, 2020·Expert Opinion on Pharmacotherapy·Shazli AzmiRayaz A Malik
Aug 26, 2020·Analytical and Bioanalytical Chemistry·Sally S El-MosallamyWael Talaat
Feb 1, 2020·Hormones : International Journal of Endocrinology and Metabolism·Marilisa QuarantaLucia Manzoli
May 1, 2020·Digestive Diseases and Sciences·A SullivanA Ruban
Feb 21, 2019·Therapeutic Advances in Endocrinology and Metabolism·Shazli AzmiRayaz A Malik
Apr 4, 2021·Journal of Clinical Medicine·Ditte S KornumKlaus Krogh
Apr 4, 2021·Journal of Personalized Medicine·Mar Sempere-BigorraOmar Cauli
Jun 26, 2021·World Journal of Diabetes·Marcio José Concepción ZavaletaLuis Alberto Concepción Urteaga
Mar 13, 2021·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Harshal S MandavdhareUsha Dutta

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