Abstract
Renovascular disease is an important cause of hypertension in children because it is potentially treatable by surgical or angioplasty techniques. The aim of this study was to assess the accuracy of radio-isotopes (DMSA, DTPA and MAG3) combined with the angiotensin converting enzyme inhibitor, captopril, in detecting children with renovascular hypertension. We retrospectively reviewed the ultrasound and pre- and post-captopril radionuclide studies (either DMSA and/or DPTA and/or MAG3) of children with sustained hypertension investigated at our institution. Renal angiography was used as the 'reference technique'. Thirty-nine children, over a period of 10 years, were evaluated: 17 (44%) children had renovascular disease that involved the proximal three divisions of the renal arteries, some of which were amenable to treatment. The overall sensitivity, specificity, positive predictive value and negative predictive value for detecting such renovascular disease, as assessed by changes between pre- and post-captopril radio-isotope studies, were disappointing at 59%, 68%, 59% and 68%, respectively. When considering only abnormalities in post-captopril studies, these indices were 82%, 41%, 52% and 75%, respectively. Three children with p...Continue Reading
Citations
Jul 24, 2008·Pediatric Radiology·Derek Roebuck
May 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aysun K BayazitAlper Soylu
Sep 17, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sameh AbdulsameaKjell Tullus
Oct 27, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kjell TullusStephen D Marks
Oct 21, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·György Sandor ReuszEva Kis
Sep 19, 2012·Current Hypertension Reports·Stephen D Marks, Kjell Tullus
Jun 9, 2000·Nuclear Medicine Communications·A MainiV Kher
Jan 24, 2007·Clinical Nuclear Medicine·Frank FiumaraGad Kainer
Nov 16, 2012·Indian Journal of Pediatrics·Meenu PandeyVirendra Kumar
Jan 18, 2006·European Journal of Pediatrics·Akira AshidaHiroshi Tamai
Aug 29, 2000·BJU International·A J Hilson
Jun 21, 2001·Clinical Nuclear Medicine·H S Broekhuizen-de GastE J Van Beek
Apr 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juliana Lacerda de Oliveira CamposAna Cristina Simões E Silva
Jul 5, 2006·Pediatrics·Rukshana ShroffKjell Tullus