The investigation of the relationships of demodex density with inflammatory response and oxidative stress in rosacea

Archives of Dermatological Research
Tuğba Falay GurDuygu Erdil

Abstract

The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis. Forty patients with rosacea and 40 age-, sex-, and skin phenotype-matched healthy volunteers were included in the study. Clinical disease severity of the patients was determined. Sebum levels were measured in both the groups, and photoaging was evaluated. Reflectance confocal microscopy was used to calculate demodex density. Serum total antioxidant capacity (TAC), total oxidant capacity (TOC), myeloperoxidase (MPO), MMP-1, MMP-9, arylesterase (ARES), interleukin-1β (IL-1β), paraoxonase-1 (PON-1), and tumor necrosis factor-α (TNF-α) levels were also analyzed. The patients with rosacea had significantly higher serum TOC and lower TAC levels (p < 0.001). The serum ARES and PON-1 levels were significantly lower (p =...Continue Reading

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Citations

Feb 26, 2019·The British Journal of Dermatology·F Forton, V De Maertelaer
May 28, 2019·The Journal of Dermatological Treatment·Haley D HeibelVivian Y Shi
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Sep 18, 2020·The Journal of Investigative Dermatology·Jamie L HardenAnne Lynn S Chang
Mar 21, 2021·Journal of Cosmetic Dermatology·Selami Aykut TemizRecep Dursun

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