The investigation of the survival time after recurrence in patients with pancreatic ductal adenocarcinoma for individualization of adjuvant chemotherapy

Surgery Today
Daisaku YamadaYuichiro Doki

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; however, the frequency of recurrence can be reduced if curative surgery following adjuvant chemotherapy is applied. At present, adjuvant chemotherapy is uniformly performed in all patients, as it is unclear which tumor types are controlled best or worst. We investigated patients with recurrence to establish the optimum treatment strategy. Of 138 patients who underwent curative surgery for PDAC, 85 developed recurrence. Comprehensive clinicopathological factors were investigated for their association with the survival time after recurrence (SAR). The median SAR was 12.6 months. Treatments for recurrence included best supportive care, GEM-based therapy and S-1. The performance status [hazard ratio (HR) 0.12, P < 0.001], histological invasion of lymph vessels (HR 0.27, P < 0.001), kind of treatment for recurrence (HR 5.0, P < 0.001) and initial recurrence site (HR 2.9, P < 0.001) were independent significant risk factors for the SAR. The initial recurrence sites were the liver (n = 21, median SAR 8.8 months), lung (n = 10, 14.9 months), peritoneum (n = 6, 1.7 months), lymph nodes (n = 6, 14.7 months), local site (n = 17, 13.9 months) and multiple sites (n = 25, 10.1 mont...Continue Reading

References

Jul 9, 2005·Surgery·Claudio BassiUNKNOWN International Study Group on Pancreatic Fistula Definition
Apr 7, 2007·Annals of Surgery·Jörg KleeffMarkus W Büchler
Jun 11, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Richard A SmithJohn P Neoptolemos
Oct 21, 2010·The British Journal of Surgery·M KandaA Nakao
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
May 31, 2011·Lancet·Audrey VincentMichael Goggins
Jun 24, 2011·The Journal of Surgical Research·Harish LavuCharles J Yeo
Jul 5, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·George J ArnaoutakisChristopher L Wolfgang
May 31, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ryan M ThomasMatthew H G Katz
Oct 10, 2013·JAMA : the Journal of the American Medical Association·Helmut OettleHanno Riess
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Mar 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A KlegerT Seufferlein
Jul 1, 2014·Surgery Today·Yoshifumi IwagamiHiroaki Nagano
May 20, 2015·Nature Cell Biology·Bruno Costa-SilvaDavid Lyden
Sep 8, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y GengZ Chen
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Feb 10, 2016·Annals of Surgical Oncology·Toshiaki KomoTaijiro Sueda
Jul 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A KlegerT Seufferlein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.