The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii

Antimicrobial Agents and Chemotherapy
Shawn R LockhartNathan P Wiederhold

Abstract

Thein vitroactivities of the novel fungal Cyp51 inhibitor VT-1129 were evaluated against a large panel ofCryptococcus neoformansandCryptococcus gattiiisolates. VT-1129 demonstrated potent activities against bothCryptococcusspecies as demonstrated by low MIC50and MIC90values. ForC. gattii, thein vitropotency was maintained against all genotypes. In addition, significantly lower geometric mean MICs were observed for VT-1129 than for fluconazole againstC. neoformans, including isolates with reduced fluconazole susceptibility.

References

Oct 9, 2004·Journal of Clinical Microbiology·Luciana TrillesJosep Guarro
Sep 21, 2006·Infectious Disease Clinics of North America·Methee Chayakulkeeree, John R Perfect
Jun 19, 2008·Antimicrobial Agents and Chemotherapy·George R ThompsonThomas F Patterson
Oct 29, 2008·Antimicrobial Agents and Chemotherapy·George R ThompsonThomas F Patterson
Dec 17, 2009·Journal of Clinical Microbiology·Naureen IqbalUNKNOWN Cryptococcus gattii Public Health Working Group
Jan 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectTania C Sorrell
May 14, 2010·Proceedings of the American Thoracic Society·Shu Shun Li, Christopher H Mody
Mar 30, 2011·Antimicrobial Agents and Chemotherapy·Nelesh P GovenderUNKNOWN Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)
Apr 13, 2012·Diagnostic Microbiology and Infectious Disease·Shawn R LockhartUNKNOWN Cryptococcus gattii PNW Public Health Working Group
Jun 21, 2014·Bioorganic & Medicinal Chemistry Letters·William J HoekstraRobert J Schotzinger

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Citations

Jan 24, 2017·Expert Review of Anti-infective Therapy·Sarah LofgrenDavid R Boulware
May 13, 2017·Nature Reviews. Drug Discovery·John R Perfect
Oct 19, 2017·The Journal of Antimicrobial Chemotherapy·Timothy J BreakMichail S Lionakis
May 16, 2018·Annals of the New York Academy of Sciences·Jennifer Geddes-McAlister, Rebecca S Shapiro
Jul 11, 2018·Antimicrobial Agents and Chemotherapy·Nathan P WiederholdThomas F Patterson
Nov 7, 2018·Antimicrobial Agents and Chemotherapy·Brian C MonkJoel D A Tyndall
Jun 19, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Apr 13, 2019·Current Topics in Medicinal Chemistry·P Marie ArockianathanRituraj Niranjan
Oct 28, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Dec 4, 2019·Antimicrobial Agents and Chemotherapy·Ren-Yi LuYuan-Ying Jiang
Mar 7, 2020·Chemical Society Reviews·Kaitlind C HowardSylvie Garneau-Tsodikova
Nov 14, 2017·Current Clinical Microbiology Reports·Jane A O'HalloranAndrej Spec
Dec 7, 2018·Current Opinion in Infectious Diseases·David S LawrenceJoseph N Jarvis
Feb 26, 2019·Frontiers in Pharmacology·Tomas Di MambroEmanuele Marra
Oct 12, 2019·The Journal of Antimicrobial Chemotherapy·Andrew T NishimotoP David Rogers
Feb 27, 2020·Open Forum Infectious Diseases·Adriana M RauseoAndrej Spec
Jul 1, 2017·PLoS Neglected Tropical Diseases·Síle F MolloyAngela Loyse
Aug 26, 2017·Drugs·Maria F Gonzalez-LaraLuis Ostrosky-Zeichner
Jun 14, 2018·Frontiers in Microbiology·Nilce M Martinez-RossiAntonio Rossi
Jun 16, 2019·International Journal of Molecular Sciences·Olufunmilayo Olukemi AkapoKhajamohiddin Syed
Dec 30, 2018·European Journal of Medicinal Chemistry·Edyta Łukowska-ChojnackaMonika Staniszewska
Mar 10, 2019·Biochimica Et Biophysica Acta. Proteins and Proteomics·Brian C MonkMikhail V Keniya
Jun 3, 2021·Current Fungal Infection Reports·Garret T Seiler, Luis Ostrosky-Zeichner
Jun 29, 2021·Expert Review of Clinical Pharmacology·Daniele R GiacobbeMatteo Bassetti
Aug 8, 2021·International Journal of Molecular Sciences·Olufunmilayo Olukemi AkapoDominik Gront

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