The involvement of a non-'bay-region' diol-epoxide in the metabolic activation of benza[a]anthracene in hamster embryo cells

Cancer Letters
C S CooperP Sims

Abstract

The major hydrocarbon-nucleoside adduct present in hydrolysates of DNA from hamster embryo cells that had been treated with 3H-labelled benz[a]anthracene in culture has been examined by chromatography on Sephadex LH-20 columns and by high-pressure liquid chromatography. The results show that this adduct most probably arises from r-8,t-9-hydroxy-t-10,11-oxy-8,9,10,11-tetrahydrobenz[a]anthracene (anti-BA-8,9.-diol 10,11-oxide). On the basis of this and other evidence, this non-bay-region diol-epoxide appears to be a reactive intermediate involved in the metabolic activation of benz[a]anthracene.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A W WoodA H Conney
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A W WoodA H Conney
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H W KingP Brookes

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