The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway

Molecular BioSystems
Jing GaoBin Yi

Abstract

Hepatopulmonary syndrome (HPS) is characterized by arterial oxygenation defects induced by intrapulmonary vascular dilation (IPVD). Pulmonary vascular remodeling (PVR) is an important pathological feature of IPVD; however, the details regarding the underlying mechanisms of this process remain undefined. Recent studies have determined that the abnormal migration of pulmonary arterial smooth muscle cells (PASMCs) plays a role in the pathogenesis of the PVR associated with HPS. Additionally, aquaporin 1 (AQP1) not only functions as a water channel molecule but also promotes cell migration by facilitating water transport in the lamellipodia of migrating cells. Common bile duct ligation (CBDL) rat is a well-accepted HPS model; we determined that the immunoperoxidase labeling of AQP1 was enhanced in the media of the pulmonary vessels in CBDL rats. HPS rat serum mediated the overexpression of AQP1 in PASMCs, and also upregulated PASMC migration. Small interfering RNAs (siRNAs) that targeted rat AQP1 caused significant downregulation of AQP1, which resulted in decreased PASMC migration. Furthermore, the inhibition of the p38-MAPK pathway abolished AQP1-dependent PASMC migration. In conclusion, this study demonstrated that AQP1 enhanced...Continue Reading

References

Jul 4, 2002·The Journal of Physiology·Peter AgreSøren Nielsen
Oct 16, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·David I Gaines, Michael B Fallon
Nov 2, 2004·The European Respiratory Journal·R Rodríguez-RoisinUNKNOWN ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee
Nov 2, 2005·Human Pathology·Peter R MazalAndrea Haitel
Mar 28, 2006·The American Journal of Pathology·Mohammad Obaidul HoqueChulso Moon
Sep 30, 2006·Circulation Research·Kurt R StenmarkMaria G Frid
Oct 24, 2006·Human Pathology·Ya Lan LiuRyohei Katoh
May 30, 2008·The New England Journal of Medicine·Roberto Rodríguez-Roisin, Michael J Krowka
Dec 27, 2008·Gastroenterology·Junlan ZhangMichael B Fallon
Jun 23, 2009·Biochemical and Biophysical Research Communications·Shusaku HayashiKoji Takeuchi
Jul 18, 2009·Glia·Eric McCoy, Harald Sontheimer
Apr 14, 2010·Journal of Viral Hepatitis·P SpagnoloR M du Bois
Dec 15, 2010·American Journal of Respiratory and Critical Care Medicine·Thenappan ThenappanStephen L Archer
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lu TieXue-Jun Li
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Li-Bo ZouJian-Zhong Sheng
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yong-Hua ShiHeng Chang
Dec 3, 2014·Stem Cells and Development·Linda Miller

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Citations

Jan 13, 2016·Trends in Immunology·Christoph A ThaissEran Elinav
Sep 19, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Bohui LiYingyu Jin
Jul 20, 2016·World Journal of Gastroenterology : WJG·Israel Grilo-Bensusan, Juan Manuel Pascasio-Acevedo
May 31, 2019·Journal of Cellular and Molecular Medicine·Jing GaoBin Yi

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