PMID: 9178855May 9, 1997Paper

The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus

Neuroscience Letters
T FukushimaS Watanabe

Abstract

We investigated the involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the photic entrainment of circadian rhythms using calmodulin inhibitors such as calmidazolium (CMZ) and trifluoperazine (TFP), and a CaMKII inhibitor, KN-62, in rats. Fos expression in the suprachiasmatic nucleus (SCN) of rats induced by photic stimulation (300 lux, 1 h) during the early subjective night of the rats was inhibited by treatment with CMZ (10 mg/kg i.p.) or TFP (20 mg/kg i.p.) 30 min before photic stimulation. With respect to the neuronal firing rate in the rat SCN slice, KN-62 and CMZ application during the early subjective night attenuated the glutamate (10 microM)-induced phase shift. The present results suggest that calmodulin and CaMKII are involved in the photic entrainment mechanism in the rodent SCN.

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Citations

Dec 11, 2013·Zoological Science·Akihito A AdachiYasufumi Shigeyoshi
Jul 25, 2007·Progress in Neurobiology·Timothy M Brown, Hugh D Piggins
Jul 26, 2007·The European Journal of Neuroscience·Boyoung LeeKarl Obrietan
Jul 16, 2015·Photochemistry and Photobiology·Maristela O PoletiniAna Maria L Castrucci
Sep 3, 2013·Cell·Aarti JagannathStuart N Peirson
Oct 7, 2014·Frontiers in Systems Neuroscience·Rajashekar IyerMartha U Gillette
Aug 18, 2004·Neurochemistry International·Diego A GolombekGabriela A Ferreyra
Mar 2, 2017·Cold Spring Harbor Perspectives in Biology·Charles N AllenChristopher S Colwell
Feb 1, 2018·The European Journal of Neuroscience·Kelin WheatonKarl Obrietan
Sep 4, 2014·PloS One·Bruno C R RamosAna Maria L Castrucci
Oct 1, 2018·The European Journal of Neuroscience·Yukihiro Yamada, Rebecca A Prosser
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Mar 13, 2020·Physiological Reviews·Jenna R M HarveyAndrea L Meredith
Jul 28, 1999·The Journal of Comparative Neurology·C F GillespieH E Albers
Jun 4, 2002·The Journal of Biological Chemistry·Greg Q ButcherKarl Obrietan
May 16, 2019·International Journal of Molecular Sciences·Sara HegaziHai-Ying Mary Cheng

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