PMID: 702949Jun 1, 1978Paper

The involvement of catecholamine in scopolamine-induced locomotor activation and rotational behaviour in mice

Japanese Journal of Pharmacology
H WatanabeK Hagino

Abstract

Scopolamine-induced locomotor activation was studied in comparison with the responses to apomorphine and methamphetamine in mice. The responses to scopolamine and methamphetamine were markedly depressed by the pretreatment with the catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine, while the activation response to apomorphine was not affected. p-Chlorophenylalanine did not affect the response to scopolamine. Phenoxybenzamine reduced the responses to scopolamine and methamphetamine, but did not affect the apomorphine response. Propranolol did not affect the responses to the three agonists, scopolamine, apomorphine and methamphetamine. Antipsychotic drugs haloperidol and pimozide reduced the responses to the three agonists. Haloperidol was especially effective in this regard. These results suggest the involvement of catecholamine in the locomotor activation produced by scopolamine. In the rotational behaviour model which is sensitive to dopamine receptor stimulating agents, effects of the three agonists were studied. Scopolamine produced the ipsilateral rotation in mice with unilateral striatal 6-hydroxydopamine-induced lesions. Methamphetamine induced the ipsilateral rotation, while apomorphine produced the contralatera...Continue Reading

Citations

Aug 10, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I SakakibaraJ Kamei
Dec 16, 2004·Journal of Pharmacological Sciences·Tomohisa MoriToshiko Sawaguchi

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