The involvement of cathepsin F gene (CTSF) in turbot (Scophthalmus maximus L.) mucosal immunity

Fish & Shellfish Immunology
Chengbin GaoChao Li

Abstract

Cathepsin F (CTSF) is a recently described papain-like cysteine protease and unique among cathepsins due to an elongated N-terminal pro-region, which contains a cystatin domain. CTSF likely plays a regulatory role in processing the invariant chain which is associated with the major histocompatibility complex (MHC) class II. In this regard, we identified the CTSF gene of turbot as well as its protein structure, phylogenetic relationships, and expression patterns in mucosal tissues following Vibrio anguillarum and Streptococcus iniae challenge. We also determined the expression patterns of CTSF in mucosal tissues after vaccinated with the formalin-inactivated V. vulnificus whole-cell vaccine. Briefly, turbot CTSF gene showed the closest relationship with that of Paralichthys olivaceus in phylogenetic analysis. And CTSF was ubiquitously expressed in all tested tissues with the highest expression level in gill. In addition, CTSF gene showed different expression patterns following different bacterial challenge. The significant quick regulation of CTSF in mucosal surfaces against infection indicated its roles in mucosal immunity. Functional studies should further characterize avail utilization of CTSF function to increase the disease...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·J S Bond, P E Butler
Feb 17, 1995·Journal of Molecular Biology·P J Berti, A C Storer
Jul 1, 1996·Applied and Environmental Microbiology·E G Biosca, C Amaro
Jan 1, 1997·Annual Review of Physiology·H A ChapmanG P Shi
Feb 7, 2001·Immunity·J A Villadangos, H L Ploegh
Aug 12, 2000·Fish & Shellfish Immunology·F Aranishi, N Mano
May 5, 2006·Tissue Antigens·T Zavasnik-Bergant, B Turk
Jan 17, 2007·Expert Opinion on Biological Therapy·Natasa ObermajerJanko Kos
Jul 10, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sangeetha SubramanianNeil W Ross
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Dec 18, 2007·FEMS Immunology and Medical Microbiology·Geovanny D Gómez, José Luis Balcázar
Jun 24, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sang Jung AhnHyung Ho Lee
Oct 11, 2011·Biologicals : Journal of the International Association of Biological Standardization·Craig A ShoemakerPhillip H Klesius
Jun 26, 2012·Nucleic Acids Research·Andreas UntergasserSteven G Rozen
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Dec 31, 2015·Tissue Barriers·Eric PeatmanBenjamin H Beck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.