PMID: 2484625Jul 1, 1989Paper

The involvement of heterochromatic damage in nickel-induced transformation

Biological Trace Element Research
K Conway, M Costa

Abstract

Nickel ions produce selective damage in heterochromatic regions of chromosomes. Male Chinese hamster embryo cells, which have heterochromatin along the entire long arm of the X-chromosome, exhibit an unusually high incidence of nickel-induced transformation compared with female cells of the same species. However, 3-methylcholanthrene, a carcinogen that produces a random distribution of chromosome damage, transforms female and male cells equally. Other species that do not have as much heterochromatin on the X-chromosome exhibit similar incidences of nickel-induced tumors in males and females. Four out of five of the male nickel-transformed Chinese hamster cell lines exhibit a deletion of the heterochromatic long arm of the X-chromosome as the only common karyotypic aberration. This result indicates that a deletion of a heterochromatic chromosomal region may be an important feature of the nickel-induced carcinogenic process. All of the male nickel transformed cells lines are able to form tumors in athymic nude mice.

References

Sep 27, 1977·Chromosoma·M T Kuo, G F Saunders
May 1, 1977·British Journal of Industrial Medicine·R DollL G Morgan
Oct 1, 1985·Chemico-biological Interactions·S R Patierno, M Costa
Sep 1, 1985·Environmental Health Perspectives·S NesnowM J Mass
Jan 1, 1971·Chromosoma·T C HsuB R Brinkley
Mar 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·T C HSU, C E SOMERS

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Citations

Apr 1, 1994·Cell Biology and Toxicology·N A LittlefieldL A Poirier
Jun 6, 1994·The Science of the Total Environment·M CostaK Salnikow
Jan 1, 1994·Environmental Health Perspectives·H M Shen, Q F Zhang
Jul 13, 2005·Mutation Research·Max CostaThomas Kluz
Jan 1, 2013·Genes·Hong SunMax Costa

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