The involvement of human organic anion transporting polypeptides (OATPs) in drug-herb/food interactions

Chinese Medicine
Youmna AliFanfan Zhou

Abstract

Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances including hormones, natural compounds and many clinically important drugs. OATP1A2, OATP2B1, OATP1B1 and OATP1B3 are the most important OATP isoforms and influence the pharmacokinetic performance of drugs. These OATPs are highly expressed in the kidney, intestine and liver, where they determine the distribution of drugs to these tissues. Herbal medicines are increasingly popular for their potential health benefits. Humans are also exposed to many natural compounds in fruits, vegetables and other food sources. In consequence, the consumption of herbal medicines or food sources together with a range of important drugs can result in drug-herb/food interactions via competing specific OATPs. Such interactions may lead to adverse clinical outcomes and unexpected toxicities of drug therapies. This review summarises the drug-herb/food interactions of drugs and chemicals that are present in herbal medicines and/or food in relation to human OATPs. This information can contribute to improving clinical outcomes and avoiding unexpected toxi...Continue Reading

References

Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·M V St-PierreT Stallmach
Mar 7, 2003·Clinical Pharmacology and Therapeutics·Jari J LiljaPertti J Neuvonen
Apr 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yunhai CuiDietrich Keppler
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Daisuke KobayashiIkumi Tamai
Sep 10, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Manfred G. IsmairGerd A. Kullak-Ublick
May 20, 2004·Drug Discovery Today·William M Atkins
Nov 3, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ichiro IeiriYuichi Sugiyama
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Verena KeitelRalf Kubitz
Jun 29, 2005·European Journal of Clinical Pharmacology·J J LiljaP J Neuvonen
Aug 6, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaodong WangMarilyn E Morris
Nov 25, 2005·British Journal of Clinical Pharmacology·Jari J LiljaPertti J Neuvonen
Sep 14, 2006·JAMA : the Journal of the American Medical Association·Shinichi KuriyamaIchiro Tsuji
Jan 12, 2007·Clinical Pharmacology and Therapeutics·H GlaeserR B Kim
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Wei ZhangHong-Hao Zhou
Nov 10, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc Le VeeOlivier Fardel
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akinobu HamadaWilliam D Figg
Dec 17, 2008·Cancer Research·Wooin LeeWael El-Rifai
Jun 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kacper A WojtalStephan R Vavricka
Jul 30, 2009·Journal of Gastroenterology and Hepatology·Mario CongiuPaul V Desmond
Nov 27, 2009·Circulation Research·Michael J KnauerRommel G Tirona
Mar 5, 2010·Fundamental & Clinical Pharmacology·Marc Le VeeOlivier Fardel
Apr 23, 2010·Journal of Natural Products·Adolf Nahrstedt, Veronika Butterweck
Jul 7, 2010·American Journal of Human Genetics·Bertrand IsidorCédric Le Caignec
Sep 16, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yumiko AkamineTsukasa Uno
Feb 1, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Megan RothBruno Hagenbuch
Apr 19, 2011·American Journal of Perinatology·Gökhan BüyükkaleAyse Gökalp
May 17, 2011·Biochemical Pharmacology·Marc Le VeeOlivier Fardel
Oct 22, 2011·British Journal of Pharmacology·Megan RothBruno Hagenbuch
Nov 29, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Lan-Xiang WuHong-Hao Zhou
Dec 27, 2011·American Journal of Human Genetics·Zhenlin ZhangYujuan Liu
Jan 11, 2012·The Journal of Clinical Investigation·Evita van de SteegAlfred H Schinkel
Sep 19, 2012·Drug Metabolism and Pharmacokinetics·Masahiro SegawaKen Iseki
Oct 4, 2012·Clinical Pharmacology and Therapeutics·M J DoltonA J McLachlan

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Citations

Nov 9, 2021·Nucleic Acids Research·Tingting FuFeng Zhu

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Methods Mentioned

BETA
glycosylation

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