The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia

Journal of Neuroimmunology
Mourad BelkhelfaChafia Touil-Boukoffa

Abstract

The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid deposits, neovascularization, neuronal hypertrophy and neuroinflammation in the hippocampus tissue. Interestingly, the neuroinflammation was characterized by a higher expression of TNF-α, IL-1β, TGF-β and iNOS which are TLR4/RelA pathway dependent. Finally, the finding of necroptosis by impaired blood supply and inflammation state suggests that the cognitive impairment was caused by vascular disease and neuroinflammation.

Citations

Oct 24, 2019·Annals of the New York Academy of Sciences·Apostolis PapaefthymiouJannis Kountouras
Jun 12, 2019·International Journal of Molecular Sciences·Virginia CipolliniFranco Giubilei
Feb 26, 2021·Neuropsychiatric Disease and Treatment·Xudong QianJian Zhang
Jan 30, 2021·Alzheimer Disease and Associated Disorders·Ashlee TurnerShantel L Duffy
Feb 4, 2021·Aging and Disease·Huang KuangShu-Long Yang
Aug 7, 2021·Nature Neuroscience·Samantha Schaeffer, Costantino Iadecola
Jan 15, 2022·Metabolic Brain Disease·Mandeep Kaur, Saurabh Sharma

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