PMID: 2495183Apr 21, 1989Paper

The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

Cell
M J LenardoD Baltimore

Abstract

The DNA binding protein NF-kappa B has been implicated in gene regulation in B and T lymphocytes. We have found that NF-kappa B also has a central role in virus induction of human beta-interferon (beta-IFN) gene expression. A critical virus-inducible element of this gene, PRDII, behaves interchangeably with the NF-kappa B binding site from the Ig kappa enhancer in both B lymphocytes and virus-infected fibroblasts. Single base substitutions that impair inducibility of the beta-IFN gene in vivo also reduce the binding of NF-kappa B to PRDII in vitro. Virus infection potently activates the binding and nuclear localization of NF-kappa B and, in pre-B lymphocytes, results in the expression of both the beta-IFN gene and the Ig kappa gene. The wide variety of cell types in which beta-interferon can be induced and the divergent set of gene induction processes involving NF-kappa B suggest that this transcription factor plays a broad role in gene regulation as a mediator of inducible signal transduction.

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Citations

Jul 1, 1992·Journal of Cellular Physiology·L Cohen, J Hiscott
Sep 24, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Josias Brito FrazãoAntonio Condino-Neto
Nov 1, 2011·Seminars in Immunopathology·Dane Parker, Alice Prince
Jul 31, 2013·Mycotoxin Research·Kei-ichi SugiyamaYoshiko Sugita-Konishi
Jan 1, 1990·Pharmacology & Therapeutics·H J Rahmsdorf, P Herrlich
Jan 1, 1991·Pharmacology & Therapeutics·R M RobertsD W Leaman
Dec 1, 1993·Antiviral Research·C W Czarniecki
Aug 1, 1990·Immunology Today·B David-WatineP Kourilsky
Dec 1, 1989·Trends in Genetics : TIG·K L Calame
Jan 1, 1990·Biochimie·G Lefranc, M P Lefranc
Jan 1, 1994·Biochimie·R Jagus, M M Gray
Jun 1, 1990·Biochimica Et Biophysica Acta·S Goodbourn
Jan 1, 1990·Progress in Growth Factor Research·G R GuyC S Peng
May 24, 2005·Biochemical and Biophysical Research Communications·Mifumi Shimomura-ShimizuKen-ichi Tanamoto
Jun 9, 2004·Developmental and Comparative Immunology·Gavan A HarrisonElizabeth M Deane
Dec 29, 1998·Biochimie·S Lopez, S Navarro
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T IwamuraT Fujita
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fulai JinRama Natarajan
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E MuñozB T Huber
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T FujitaJ Vilcek
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M P DuyaoG E Sonenshein
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L A Whittemore, T Maniatis

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