Jan 29, 1997

The involvement of sigma receptors in the choice reaction performance deficits induced by phencyclidine

European Journal of Pharmacology
J JinS Watanabe


The present study investigated the effects of phencyclidine (PCP) on choice reaction in a 3-choice serial reaction time task for studying attentional function. PCP (3.2 mg/kg) significantly delayed choice reaction time and reduced choice accuracy. A novel sigma receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) at 3.2 mg/kg, and 1-(cyclopropylmethyl)-4-[2'-4"-fluorophenyl)-2'-oxoethyl]piperidin e HBr (DuP734) at 1.0-3.2 mg/kg, but not 4-[2'-(4"-cyanophenyl)-2'-oxoethyl]-1-(cyclopropylmethyl)pip eridine (XJ448), antagonized both the delayed choice reaction time and the decreased choice accuracy elicited by PCP administration. The antagonism induced by NE-100 was blocked by the sigma receptor agonist (+)-N-allylnormetazocine HCl [(+)-SKF10,047]. These findings indicated that PCP (3.2 mg/kg) significantly induced attention deficit in a 3-choice serial reaction time task, and that this process may be mediated by sigma receptors.

Mentioned in this Paper

Antipsychotic Effect
Receptors, sigma
Reaction Time
Phencyclidine Hydrobromide
Antagonist Muscle Action
SK&F 10047, monooxalate

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