The involvement of the progesterone receptor in PIBF and Gal-1 expression in the mouse endometrium

American Journal of Reproductive Immunology : AJRI
Biserka Mulac-JericevicJ Szekeres-Bartho

Abstract

The progesterone-regulated genes, PIBF and Gal-1, are key players in the feto-maternal immunological interaction. This study aims to investigate the expression of PIBF and Gal-1 in WT and progesterone receptor KO models as well as subsequent effects of PIBF on decidualization of stromal cells. PRAKO, PRBKO and PRKO BALB/c mice were used for assessing the role of PR isoforms in PIBF induction. PIBF- and Gal-1 mRNA expression in the uterus was tested by real-time PCR. The effect of PIBF on decidualization of endometrial stromal cells was verified by anti-desmin immunofluorescence. Immunohistochemistry was used for testing PIBF expression in the uterus. Gal-1, ERα and PR positive decidual NK cells were detected by immunofluorescence. PIBF mRNA was significantly increased in progesterone-treated WT mice, but not in PRKO and PRAKO mice. PIBF protein expression was reduced in the endometria of PRKO and PRAKO, but not in PRBKO mice. During a 6-day culture, PIBF induced decidual transformation of endometrial stromal cells. PIBF expression in the mouse uterus was highest during the implantation window, while Gal-1 mRNA expression continuously increased between day 2.5 and day 11.5 of gestation. Decidual NK cells express Gal-1 and ERα, b...Continue Reading

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Citations

Feb 11, 2020·Frontiers in Immunology·Maria Emilia Solano, Petra Clara Arck
Mar 29, 2020·Frontiers in Immunology·Timea CsabaiJulia Szekeres-Bartho
Aug 17, 2021·Frontiers in Immunology·Marie-Pierre PiccinniJulia Szekeres-Bartho

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