PMID: 2827859Dec 1, 1987Paper

The involvement of the sympathetic nervous system in the centrogenic pressor and tachycardiac effects of prostaglandins E2 and F2 alpha in anaesthetised cats

Brain Research
T S RaoU Nayar

Abstract

The intracerebroventricular (i.c.v.) administration of prostaglandin E2 (PGE2, 1 micrograms) and prostaglandin F2 alpha (PGF2 alpha, 10 micrograms) produced prolonged pressor and tachycardiac responses in chloralose-anaesthetised cats. Phenoxybenzamine-pretreatment completely prevented the pressor response without altering the tachycardiac response, whereas propranolol intervention completely inhibited the tachycardiac response and also attenuated the pressor response. The pretreatment with pentolinium completely antagonised both the pressor and tachycardiac responses to i.c.v. PGE2 and PGF2 alpha. The results suggest that the centrally administered PGE2 and PGF2 alpha augment sympathetic outflow to the heart and vascular system and thereby cause excitatory cardiovascular responses in anaesthetised cats.

References

Jan 1, 1979·Annual Review of Physiology·L S Wolfe, F Coceani
Jun 28, 1979·Psychopharmacology·R BrusJ Zabawska
Jul 1, 1978·Brain Research Bulletin·G CsehM Palkovits
Jan 1, 1979·Annual Review of Physiology·H R Behrman
Mar 1, 1979·Prostaglandins·H KarppanenA Eskeli-Kaivosoja
Nov 1, 1977·Stroke; a Journal of Cerebral Circulation·A A HagenJ T Robertson
Jul 1, 1976·Canadian Journal of Biochemistry·L S WolfeH M Pappius
Aug 1, 1965·The Journal of Pharmacy and Pharmacology·G Leszkovszky, L Tardos
May 1, 1966·The Journal of Pharmacy and Pharmacology·W MurmannM Saccani-Guelfi
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·W J Lang, L Pearson
Jul 1, 1971·Neuropharmacology·J G Bainbridge, D T Greenwood
Sep 1, 1974·Journal of Neurosurgery·E La TorreD Grossi-Belloni
Mar 1, 1971·British Journal of Pharmacology·H A LaveryG C Scroop
May 1, 1966·British Journal of Pharmacology and Chemotherapy·G L AvanzinoJ H Wolstencroft
Jan 1, 1983·General Pharmacology·E K Chiu, J S Richardson
Jan 28, 1983·European Journal of Pharmacology·E K Chiu, J S Richardson
Jan 1, 1982·Pharmacology & Therapeutics·R P White, A A Hagen
Jan 14, 1982·Brain Research·G FeuersteinD M Jacobowitz

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Citations

Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T C Tai, S L Adamson
Aug 15, 1992·The Journal of Comparative Neurology·C D BrederC B Saper

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