The ionic mechanism of postsynaptic inhibition in motoneurones of the frog spinal cord.

Neuroscience
C P Bührle, U Sonnhof

Abstract

The ionic mechanism of postsynaptic inhibition in frog spinal motoneurones was studied with conventional and with ion-sensitive microelectrodes. In these neurones the inhibitory postsynaptic potential was depolarizing, its reversal potential being 15 mV less negative than the resting membrane potential. During the inhibitory postsynaptic potential the input resistance of the motoneurones was reduced to 20% of the resting value, indicating a strong increase of membrane conductance. The Cl- equilibrium potential calculated from intra- and extracellular Cl- activity measurements coincided with the reversal potential of the inhibitory postsynaptic potential to within a few millivolts. During repetitive inhibitory postsynaptic activity the intracellular Cl- activity decreased markedly, while the extracellular Cl- activity increased slightly. These changes of intra- and extracellular Cl- activities were no longer found after suppression of the inhibitory postsynaptic potential by strychnine. Blockade of an active, inward-going Cl- transport system in motoneurones by NH+4 led to a shift of the Cl- equilibrium potential and the reversal potential of the inhibitory postsynaptic potential towards the resting membrane potential. After pro...Continue Reading

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Citations

Jul 1, 1982·Pflügers Archiv : European journal of physiology·B Buchert-Rau, U Sonnhof
Mar 1, 1994·Progress in Neurobiology·K Kaila
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·G V Obrocea, M E Morris
May 6, 2004·Biographical Memoirs of Fellows of the Royal Society·D R Curtis, P Andersen
Nov 1, 1987·The International Journal of Neuroscience·H HydénA Palm

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