The iron-chelating potential of silybin in patients with hereditary haemochromatosis.

European Journal of Clinical Nutrition
Carol HutchinsonCatherine A Geissler

Abstract

Milk thistle contains silybin, which is a potential iron chelator. We aimed to determine whether silybin reduced iron absorption in patients with hereditary haemochromatosis. In this crossover study, on three separate occasions, 10 patients who were homozygous for the C282Y mutation in the HFE gene (and fully treated) consumed a vegetarian meal containing 13.9 mg iron with: 200 ml water; 200 ml water and 140 mg silybin (Legalon Forte); or 200 ml tea. Blood was drawn once before, then 0.5, 1, 2, 3 and 4 h after the meal. Consumption of silybin with a meal resulted in a reduction in the postprandial increase in serum iron (AUC±s.e.) compared with water (silybin 1726.6±346.8 versus water 2988.8±167; P<0.05) and tea (silybin 1726.6±346.8 versus tea 2099.3±223.3; P<0.05). In conclusion, silybin has the potential to reduce iron absorption, and this deserves further investigation, as silybin could be an adjunct in the treatment of haemochromatosis.

References

Feb 1, 1977·The American Journal of Clinical Nutrition·J D Cook, E R Monsen
Jun 19, 2001·Journal of Inorganic Biochemistry·M BorsariF Borella
Oct 8, 2004·The British Journal of Nutrition·Michael HoppeLeif Hallberg
Jun 15, 2006·The Journal of Nutrition·Rana E ConwayJonathan J Powell
May 7, 2008·Journal of Clinical Gastroenterology·Julie M BaresKris V Kowdley

❮ Previous
Next ❯

Citations

Oct 2, 2012·Annual Review of Pharmacology and Toxicology·Shaina L ByrneMarianne Wessling-Resnick
Mar 22, 2016·Advances in Pharmacological Sciences·Hadi Darvishi KhezriArash Hadian Amree
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christina N KontoghiorgheGeorge J Kontoghiorghes
Apr 30, 2013·International Immunopharmacology·Marjan GharagozlooZahra Amirghofran
Oct 11, 2016·British Journal of Haematology·Eva Rombout-SestrienkovaGer H Koek
Aug 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Sael Casas-Grajales, Pablo Muriel
May 10, 2019·Phytotherapy Research : PTR·Vahid SoleimaniGholamreza Karimi
Mar 7, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Fernanda Caetano Camini, Daniela Caldeira Costa
Dec 14, 2017·Phytotherapy Research : PTR·Hadi Darvishi-KhezriAily Aliasgharian
May 21, 2020·International Journal of Molecular Sciences·Raffaela RamettaPaola Dongiovanni
Mar 7, 2021·International Journal of Molecular Sciences·Coralia CotoraciAnca Hermenean

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.