The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.

Infection and Immunity
Sabine ChlostaBobby J Cherayil

Abstract

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

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Citations

May 15, 2007·Immunologic Research·Chittur V Srikanth, Bobby J Cherayil
Sep 30, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Bobby J Cherayil
Apr 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Robert E Fleming
Dec 2, 2008·Archives of Dermatological Research·Luiz Ricardo Goulart, Isabela Maria Bernardes Goulart
Dec 17, 2010·Immunologic Research·Bobby J Cherayil
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May 24, 2008·The New England Journal of Medicine·Stephen M Graham
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