The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells

The Journal of Nutritional Biochemistry
Fang DuYa Ke

Abstract

The mechanism by which hepcidin controls cellular iron release protein ferroportin 1 (Fpn1) in macrophages has been well established. However, little is known about the effects of hepcidin on cellular iron uptake proteins. Here, we demonstrated for the first time that hepcidin can significantly inhibit the expression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 in addition to Fpn1, and therefore reduce transferrin-bound iron and non-transferrin-bound iron uptake and also iron release in J774 macrophages. Analysis of mechanisms using the iron-depleted cells showed that hepcidin has a direct inhibitory effect on all iron transport proteins we examined. Further studies demonstrated that the down-regulation of TfR1 induced by hepcidin is associated with cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA), probably being mediated by the cAMP-PKA pathway in J774 macrophages.

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Citations

Apr 18, 2013·PloS One·Lorena Fernandes ArrudaEgle Machado de Almeida Siqueira
Nov 5, 2016·European Journal of Pharmacology·Yun-Ting ZhangZhong-Ming Qian
Oct 30, 2018·Journal of Cellular Physiology·Meng-Wan ZhangZhong-Ming Qian
Jun 14, 2019·Biological Reviews of the Cambridge Philosophical Society·Zhong-Ming Qian, Ya Ke
Jun 8, 2017·Frontiers in Physiology·Yu-Fu ZhouYa Ke
Dec 29, 2018·International Journal of Molecular Sciences·Yafang WangYi Chen
Nov 23, 2017·Frontiers in Molecular Neuroscience·Fa-Li ZhangZhong-Ming Qian
Jan 25, 2021·Free Radical Biology & Medicine·Qinjie LiuJianan Ren
Sep 16, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Guang YangZhong-Ming Qian
Jan 11, 2021·Molecular and Cellular Neurosciences·Chao ZhangZhong-Ming Qian

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