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The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

The Journal of Experimental Medicine

Jun 21, 2017

Stephen T FerrisJavier A Carrero

Abstract

We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1(-/-), and B6.g7 mice. Islet macrophages expressed an activation signature with high expression of Tnf, Il1b, and MHC-II at both the transcript a...read more

Mentioned in this Paper

Immune Response
Flow Cytometry
Immune System
Il1b
RAG1 gene
Lung
C57BL/6 Mouse
Entire Gastrointestinal Tract
Interleukin-1
Transcription, Genetic
30
3
43
Paper Details
References
  • References77
  • Citations12
12345...
  • References77
  • Citations12
12

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The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

The Journal of Experimental Medicine

Jun 21, 2017

Stephen T FerrisJavier A Carrero

PMID: 28630088

DOI: 10.1084/jem.20170074

Abstract

We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1(-/-), and B6.g7 mice. Islet macrophages expressed an activation signature with high expression of Tnf, Il1b, and MHC-II at both the transcript a...read more

Mentioned in this Paper

Immune Response
Flow Cytometry
Immune System
Il1b
RAG1 gene
Lung
C57BL/6 Mouse
Entire Gastrointestinal Tract
Interleukin-1
Transcription, Genetic
30
3
43

Feeds With Similar Papers

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Inflammation & Obesity

Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state. Discover the latest research on inflammation and obesity here.

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Paper Details
References
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12345...
  • References77
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12

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