The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth.

Molecular Cancer
Sofia BellouT Fotsis

Abstract

Increased consumption of plant-based diets has been linked to the presence of certain phytochemicals, including polyphenols such as flavonoids. Several of these compounds exert their protective effect via inhibition of tumor angiogenesis. Identification of additional phytochemicals with potential antiangiogenic activity is important not only for understanding the mechanism of the preventive effect, but also for developing novel therapeutic interventions. In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have screened a set of hitherto untested phytoestrogen metabolites concerning their anti-angiogenic effect, using endothelial cell proliferation as an end point. Here, we show that a novel phytoestrogen, 6-methoxyequol (6-ME), inhibited VEGF-induced proliferation of human umbilical vein endothelial cells (HUVE) cells, whereas VEGF-induced migration and survival of HUVE cells remained unaffected. In addition, 6-ME inhibited FGF-2-induced proliferation of bovine brain capillary endothelial (BBCE) cells. In line with its role in cell proliferation, 6-ME inhibited VEGF-induced phosphorylation of ERK1/2 MAPK, the key cascade respon...Continue Reading

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Citations

Feb 4, 2016·Cancer Cell International·Ichrak Riahi-ChebbiKhadija Essafi-Benkhadir
Dec 17, 2016·Molecular Nutrition & Food Research·Carmen DinizIsabel M P L V O Ferreira
May 5, 2020·Frontiers in Bioengineering and Biotechnology·Maria MarkouEleni Bagli
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ludmila KřížováTomáš Kašparovský
Mar 16, 2021·Frontiers in Pharmacology·Dezhi PanMinhui Li
Nov 9, 2021·Frontiers in Oncology·Ruyi LiZhe-Sheng Chen

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Methods Mentioned

BETA
xenograft
FCS
Fluorescence Activated Cell Scanner
Reverse Transcription-PCR
lavage
flow cytometry
acylation

Software Mentioned

metamorph

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