The isolation and physiology of inhibin and related proteins

Biology of Reproduction
D M de Kretser, D M Robertson

Abstract

Inhibin, a glycoprotein that preferentially suppresses follicle-stimulating hormone (FSH) secretion, has been isolated from follicular fluid as a heterodimer of two dissimilar subunits linked by disulphide bonds. The larger subunit is termed alpha and the smaller is designated beta. Two forms of inhibin termed A and B have been isolated, the differences being due to variations in the amino acid sequence of the beta-subunit; Inhibin A consists of alpha-beta and Inhibin B of alpha-beta B. Dimers of the beta-subunit, termed activins, have also been found in follicular fluid; these stimulate pituitary FSH secretion. Inhibin is produced in the female by the granulosa cell and corpus luteum under the control of FSH and luteinizing hormone (LH), respectively. The levels in serum rise to peak at mid-cycle and in the mid-luteal phase of the human menstrual cycle, and decline prior to menstruation. In pregnancy, the late-luteal phase decline in inhibin does not occur and the levels increase slowly. Studies suggest that the levels in pregnancy arise from an embryonic source, particularly the placenta. In the male, inhibin is produced by the Sertoli cells under the control of FSH by mechanisms involving cyclic adenosine 3', 5'-monophosphat...Continue Reading

Citations

Mar 1, 1995·Molecular Reproduction and Development·F GandolfiA Lauria
Jul 1, 1992·Cell Biology and Toxicology·H LejeuneJ M Saez
Aug 1, 1993·Cell and Tissue Research·M K VliegenE Nieschlag
May 22, 2008·Pituitary·J Lindholm, E Husted Nielsen
Mar 5, 1990·Molecular and Cellular Endocrinology·D M de Kretser
Mar 26, 1990·Molecular and Cellular Endocrinology·A J GrootenhuisF H de Jong
Jan 2, 1990·Molecular and Cellular Endocrinology·I A KlaijJ A Grootegoed
Jan 1, 1994·Domestic Animal Endocrinology·J F RoserE Hoye
Jan 1, 1993·Reproductive Toxicology·F H Comhaire
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·F H De JongJ G Klijn
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·O AvalletJ M Saez
Apr 25, 2000·Molecular and Cellular Endocrinology·D M de KretserK A Loveland
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·D L HealyD De Kretser
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M RobertsonD M de Kretser
Mar 10, 2012·Human Reproduction·C Desdoits-LethimonierB Jégou
Sep 18, 2009·Human Reproduction Update·Claire L BorgMoira K O'Bryan
May 1, 1997·The American Journal of Surgical Pathology·M RishiF A Tavassoli
Jun 1, 1992·International Journal of Andrology·K S HurkadliA R Sheth
Sep 1, 1992·Journal of Pineal Research·L Bhagat, S Duraiswami
Aug 19, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C Peng, S T Mukai
Feb 2, 2008·The Journal of Reproduction and Development·Manila SedqyarKazuyoshi Taya
Dec 18, 1998·Journal of Endocrinological Investigation·J E HallW F Crowley
Feb 18, 2016·Human Reproduction Update·R Wijayarathna, D M de Kretser
Dec 1, 1992·Annals of Medicine·H G Burger

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