PMID: 1205452Nov 1, 1975Paper

The isolation of the urogastrones - inhibitors of gastric acid secretion - from human urine

Hoppe-Seyler's Zeitschrift für physiologische Chemie
H Gregory, I R Willshire

Abstract

It has been known for over thirty years that extracts of human urine could cause inhibition of gastric acid secretion. The active principle was called urogastrone and this has now been isolated using a series of twelve simple stages of partition, gel and ion-exchange chromatography. In fact two products were obtained, each in a yeild of less than 1 mg per 1 000 l urine, which represented an overall recovery of 3 - 5%. These materials were biologically indistinguishable, causing inhibition of gastric acid secretion in a variety of circumstances at doses of less than 1 mug/kg. The purified urogastrones were found to be acidic polypeptides composed of 53 and 52 amino acid residues with three internal disulphide bonds, and they differed by only one arginine residue. Neither threonine nor phenylalanine residues were present in the urogastrones.

Citations

Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·C CallegariD A Fisher
Sep 30, 1985·Biochemical and Biophysical Research Communications·M KurobeK Hayashi
Jan 1, 1990·The International Journal of Biochemistry·S L WangB L Slomiany
Jan 1, 1994·Life Sciences·M D Hollenberg
Dec 30, 1986·Regulatory Peptides·A P SavageS R Bloom
Nov 20, 1992·Regulatory Peptides·E NexøM R Hansen
Jan 1, 1992·Progress in Growth Factor Research·S A Prigent, N R Lemoine
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M S UrdeaP J Barr
Sep 24, 2005·Molecular Biology of the Cell·James M MullinChristian Sell
Aug 11, 1982·Nucleic Acids Research·J SmithL D Bell
Jul 15, 1987·European Journal of Biochemistry·J M Jaspar, P Franchimont
Mar 10, 1979·British Medical Journal
Jul 1, 1983·The Journal of Clinical Investigation·Y Oka, D N Orth
Aug 2, 2012·World Journal of Gastroenterology : WJG·Silvia SpecaGiovanni Latella
Mar 1, 1997·Journal of Pharmaceutical Sciences·B S KuoD S Wright
Jan 1, 1990·Annals of the New York Academy of Sciences·J ColletteP Franchimont
Jan 1, 1990·Archives of Oral Biology·S L WangB L Slomiany
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·J ColletteP Franchimont
Nov 1, 1985·European Journal of Cancer & Clinical Oncology·J M Jaspar, P Franchimont
Jan 1, 1984·Journal of Cellular Biochemistry·H S EarpJ Blaisdell
Apr 14, 1986·Biochemical and Biophysical Research Communications·K MoriK Hayashi
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·E NexøM D Hollenberg
Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U MartiA L Jones
Feb 1, 1989·British Journal of Obstetrics and Gynaecology·R HaighR D Boyd
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J St Hilaire, A L Jones
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·S Dagogo-Jack
Jan 1, 1977·International Journal of Peptide and Protein Research·H Gregory, B M Preston
Sep 15, 1989·Biochemical and Biophysical Research Communications·M FuruyaK Hirayama
Aug 1, 1980·Archives of Biochemistry and Biophysics·P Berhanu, M D Hollenberg
Mar 15, 1982·Biochemical and Biophysical Research Communications·T ChibaT Fujita
Aug 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J W KonturekS J Konturek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.