The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: the study protocol

Multidisciplinary Respiratory Medicine
Stefano AlibertiIRENE Network

Abstract

A substantial increase in pulmonary and extra-pulmonary diseases due to non-tuberculous mycobacteria (NTM) has been documented worldwide, especially among subjects suffering from chronic respiratory diseases and immunocompromised patients. Many questions remain regarding the epidemiology of pulmonary disease due to NTM (NTM-PD) mainly because reporting of NTM-PD to health authorities is not mandated in several countries, including Italy. This manuscript describes the protocol of the first Italian registry of adult patients with respiratory infections caused by NTM (IRENE). IRENE is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory isolate or those with NTM-PD. A total of 41 centers, including mainly pulmonary and infectious disease departments, joined the registry so far. Adult patients with all of the following are included in the registry: 1) at least one positive culture for any NTM species from any respiratory sample; 2) at least one positive culture for NTM isolated in the year prior the enrolment and/or prescribed NTM treatment in the year prior the enrolment; 3) given consent to inclusion in the study. No exclusion criteria are applied to the study...Continue Reading

References

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Citations

Dec 1, 2018·The European Respiratory Journal·Stefano AlibertiUNKNOWN EMBARC Clinical Research Collaboration
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Stefano Aliberti, James D Chalmers
Feb 23, 2020·Archivos de bronconeumología·Miguel Angel Martinez-GarcíaUNKNOWN en representación del Grupo Español del Registro de Bronquiectasias (RIBRON)

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Methods Mentioned

BETA
bronchoalveolar lavage

Clinical Trials Mentioned

NCT03339063

Software Mentioned

IRENE
EMBARC

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