The J beta segment of the T cell receptor contributes to the V beta-specific T cell expansion caused by staphylococcal enterotoxin B and Urtica dioica superantigens

European Journal of Immunology
P MusetteG Gachelin

Abstract

We have used a new polymerase chain reaction-based technique to analyze at the clonal level the CDR3 diversity and the J beta usage associated with the V beta-dependent T cell receptor (TCR) recognition of two superantigens: the staphylococcal enterotoxin B and the Urtica dioica agglutinin. Our results show that subset of J beta elements is preferentially expanded in a given V beta family, independently of the nature of the superantigen. By contrast, the CDR3 loop does not contribute significantly to the T cell expansion induced by the superantigens. We conclude that the J beta segment of the TCR beta chain, but not the CDR3 region, participates in superantigen binding, presumably by influencing the quaternary structure of the TCR beta chain.

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Citations

Mar 21, 1998·The Journal of Experimental Medicine·A S HodtsevD N Posnett
Jul 17, 1998·The Journal of Clinical Investigation·F Rieux-LaucatJ P De Villartay
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexis ColletteSylviane Pied
Aug 2, 2000·The American Journal of Clinical Nutrition·A T BorchersM E Gershwin
Nov 25, 2003·Clinical and Experimental Immunology·D G HaegertV Gadag

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