The joint association of insulin sensitivity and physical activity on the skeletal muscle mass and performance in community-dwelling older adults

Experimental Gerontology
Chuan-Wei YangCheng-Chieh Lin

Abstract

Many well-known risk factors that may lead to sarcopenia are already discovered. However, their combined effects on sarcopenia components remain unclear. This study aims to explore the joint association of physical activity and insulin sensitivity on skeletal muscle mass and performance of Taiwanese elder people from a metropolitan community. The study sample involved 844 elders who were examined through dual energy X-ray absorptiometry and who underwent tests for fasting blood glucose and serum insulin level. The homeostasis model assessment (HOMA-IR) equation estimated insulin sensitivity. Physical performance was assessed by grip strength and walking speed, while physical activity status was assessed using the questionnaires answered by the participants. After multivariate adjustment, the mean height- and weight-adjusted skeletal muscle indexes (SMIs) for old people in the highest tertile of HOMA-IR values were 6.7kg/m2 and 27.9%, respectively, which were significantly lower than those of old people in the lowest tertile of HOMA-IR values. Compared with physically active elders with the lowest tertile of HOMA-IR values, the physically inactive elders with the highest tertile of HOMA-IR values had significantly low means in t...Continue Reading

References

Nov 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·W M Kohrt, J O Holloszy
Jul 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D M BuchnerE H Wagner
Apr 29, 1999·Mechanisms of Ageing and Development·R N BaumgartnerP J Garry
Oct 21, 2000·European Journal of Clinical Nutrition·R Roubenoff
Oct 24, 2006·International Journal of Epidemiology·Catharine R GaleAvan Aihie Sayer
May 28, 2009·European Journal of Clinical Nutrition·U S UnniA V Kurpad
Jun 25, 2009·Diabetes Care·Seok Won ParkUNKNOWN Health, Aging, and Body Composition Study
Jul 2, 2009·Australasian Journal on Ageing·Thorlene EgertonAndrew G Cresswell
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Aug 10, 2011·Clinics in Geriatric Medicine·Stéphane WalrandYves Boirie
Aug 10, 2011·Clinics in Geriatric Medicine·Fabien PillardYves Rolland
Apr 21, 2012·Advances in Nutrition·John W CarboneStefan M Pasiakos
May 15, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Karen KwanMelinda L Irwin
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Joseph E OstlerMuthu Periasamy
Jan 24, 2014·Geriatrics & Gerontology International·Kyung-Soo KimSeok Won Park

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Citations

Nov 6, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Mariam El AssarLeocadio Rodríguez Mañas
Jun 13, 2020·Frontiers in Endocrinology·Rodrigo Pérez-RodríguezLeocadio Rodríguez-Mañas
Jan 17, 2021·Progress in Cardiovascular Diseases·Chueh-Lung HwangShane A Phillips
Feb 12, 2021·Scientific Reports·Naoki KuramotoWataru Ogawa
Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci
Feb 9, 2020·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
May 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alexandra M WennbergKarin Modig

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