The joint effects of sulfonamides and quorum sensing inhibitors on Vibrio fischeri: Differences between the acute and chronic mixed toxicity mechanisms

Journal of Hazardous Materials
Ting WangYin Liu

Abstract

Quorum sensing inhibitors (QSIs) are considered to be promising antibiotic alternatives and will be increasingly exposed to the environment together with antibiotics after their research and development process; it is therefore necessary to study the joint effects of QSIs and antibiotics. In this study, single and mixed toxicity of sulfonamide (SAs) and QSIs under acute and chronic conditions and their corresponding toxicity mechanisms were investigated. The results indicated that the acute joint effect was extremely complex, ranging from an antagonistic to synergistic response, while the chronic joint effect was primarily an antagonistic response. Using a molecular docking and regression model, we found that the acute joint effect could be determined by the hydrion's, ability to be oxidized, as well as the binding energy. The chronic joint effect was primarily an antagonistic response, which was due to the QSI competing against AHL for luxR generated by SAs, leading to negative effects of the QSI-luxR complexes on luxI. This phenomenon eventually weakened the stimulatory effect caused by SAs. Finally, the main differences between acute and chronic mixtures were analyzed: (1) The target protein was different between acute and c...Continue Reading

References

Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Y Hostetler, L B Hall
Apr 1, 1982·European Journal of Biochemistry·M KurfürstJ W Hastings
Jul 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alun Bermingham, Jeremy P Derrick
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ee-Been GohJulian Davies
Jun 4, 2004·Journal of Bacteriology·Claudia Lupp, Edward G Ruby
May 5, 2005·Microbiology·Thomas Bovbjerg RasmussenMichael Givskov
Mar 1, 2006·International Journal of Medical Microbiology : IJMM·Thomas B Rasmussen, Michael Givskov
Mar 1, 2006·International Journal of Medical Microbiology : IJMM·Grace YimJulian Davies
Dec 31, 2010·Environmental Toxicology and Chemistry·Chun-Mei Zhao, Wen-Xiong Wang
Apr 15, 2011·Current Opinion in Microbiology·Tom DefoirdtPeter Bossier
Nov 4, 2011·Nature Reviews. Microbiology·Karen BushHelen I Zgurskaya
Nov 6, 2012·Cold Spring Harbor Perspectives in Medicine·Steven T Rutherford, Bonnie L Bassler
Nov 13, 2012·Biotechnology Advances·Vipin Chandra Kalia
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yong-Guan ZhuJames M Tiedje
Oct 16, 2013·Trends in Microbiology·Tom DefoirdtTom Coenye

❮ Previous
Next ❯

Citations

Jan 16, 2019·International Journal of Environmental Research and Public Health·In-Hyuk BaekJongwoon Kim
Mar 5, 2019·Dose-response : a Publication of International Hormesis Society·Yueheng ZhangYinjiang Zhang
Feb 7, 2018·Ecotoxicology and Environmental Safety·Siyu WuDefu He
Mar 19, 2021·Ecotoxicology and Environmental Safety·Naima HamidDe-Sheng Pei
Jul 3, 2021·International Journal of Environmental Research and Public Health·Nur Adila AdnanMohd Yunus Abd Shukor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.