The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome

Current Rheumatology Reports
Rohan WillisA R Brasier

Abstract

Pathogenic antiphospholipid antibodies (aPL) are the driving factors of recurrent pregnancy loss and thrombosis that characterize antiphospholipid syndrome (APS). Current evidence indicates that aPL induce a procoagulant phenotype in the vasculature and abnormal cellular proliferation and differentiation in placental tissues to cause the typical clinical features; however, the molecular mechanisms underlying these processes remain incompletely understood. Inflammation serves as a necessary link between the observed procoagulant phenotype and actual thrombus development and is an important mediator of the placental injury in APS patients. However, the underlying mechanisms for these events have also not been fully elucidated. In this review, we will outline the available data that give us our current understanding of the pathophysiology of APS, especially as it relates to the development of thromboembolic and obstetric pathological phenomena in these patients. We will also describe the intracellular signaling pathways activated by aPL in various cellular subtypes and outline the current evidence linking these pathways to clinical phenotypes. Finally, we will discuss the implications of distinct molecular patterns defining clinic...Continue Reading

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Citations

Sep 1, 2015·Autoimmunity Reviews·Lucas L van den HoogenRonald H W M Derksen
Jul 6, 2016·Clinical Reviews in Allergy & Immunology·Steven R Binder, Christine M Litwin
Mar 25, 2017·British Journal of Haematology·Deepa R J Arachchillage, Mike Laffan
Apr 1, 2017·Current Rheumatology Reports·Karl J LacknerNadine Müller-Calleja
Nov 10, 2018·Expert Review of Clinical Immunology·Karl J Lackner, Nadine Müller-Calleja
Jul 3, 2016·Clinical Rheumatology·Mirjana Bećarević, Svetlana Ignjatović
Dec 7, 2019·Hematology·Ecem SevimDoruk Erkan

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