The journey of Zika to the developing brain.

Molecular Biology Reports
Francesca RombiSharon Yeoh

Abstract

Zika virus is a mosquito-borne Flavivirus originally isolated from humans in 1952. Following its re-emergence in Brazil in 2015, an increase in the number of babies born with microcephaly to infected mothers was observed. Microcephaly is a neurodevelopmental disorder, characterised phenotypically by a smaller than average head size, and is usually developed in utero. The 2015 outbreak in the Americas led to the World Health Organisation declaring Zika a Public Health Emergency of International Concern. Since then, much research into the effects of Zika has been carried out. Studies have investigated the structure of the virus, its effects on and evasion of the immune response, cellular entry including target receptors, its transmission from infected mother to foetus and its cellular targets. This review discusses current knowledge and novel research into these areas, in hope of developing a further understanding of how exposure of pregnant women to the Zika virus can lead to impaired brain development of their foetus. Although no longer considered an epidemic in the Americas, the mechanism by which Zika acts is still not comprehensively and wholly understood, and this understanding will be crucial in developing effective vaccin...Continue Reading

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Citations

Dec 12, 2020·Scientific Reports·Larissa Daniele BoberminDiogo Onofre Souza
Jun 29, 2021·Trends in Analytical Chemistry : TRAC·Mazhar SherStefano Cinti
Jul 3, 2021·Biomedicines·Philma Glora MuthurajSathish Kumar Natarajan

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