The journey to establish purinergic signalling in the gut

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
G Burnstock

Abstract

Although the concept of purinergic signalling arose from experiments designed to find the identity of the non-adrenergic, non-cholinergic (NANC) inhibitory neurotransmitter in the gut, it has taken many years for the more general importance of the various roles of ATP as a physiological messenger in the gut to be recognized. Firstly, vasoactive intestitial polypeptide (VIP) and later nitric oxide (NO) were considered the NANC transmitter and it was only later, after the concept of cotransmission was established, that ATP, NO and VIP were recognized as cotransmitters in NANC nerves, although the proportions vary in different gut regions. Recently, many purinoceptor subtypes have been identified on myenteric, submucosal motor, sensory and interneurons involved in synaptic neurotransmission and neuromodulation and reflex activity of several kinds, including ascending excitatory and descending inhibitory reflex pathways. Nucleotide receptors have been shown to be expressed on enteric glial cells and interstitial cells of Cajal. Purinergic mechanosensory transduction, involving release of ATP from mucosal epithelial cells during distension to stimulate subepithelial nerve endings of intrinsic and extrinsic sensory nerves to modulate...Continue Reading

References

Mar 5, 1991·European Journal of Pharmacology·A BelaiG Burnstock
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Aug 1, 1995·Surgery·B C Kimball, M W Mulholland
Apr 3, 2001·Trends in Pharmacological Sciences·G Burnstock
May 11, 2001·Scandinavian Journal of Gastroenterology·K SzentpáliM Boros
Aug 1, 1976·Neuroscience·G Burnstock
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y YiangouP Anand
Oct 2, 2001·The Journal of Comparative Neurology·F L ChristofiH J Cooke
Oct 31, 2001·Journal of Pediatric Surgery·P FacerP Anand
May 31, 2002·Autonomic Neuroscience : Basic & Clinical·G Burnstock, S Lavin
Jan 16, 2003·Neuropharmacology·C GiaroniG Burnstock
Jun 19, 2003·The Journal of Physiology·Xiaochun BianJames J Galligan
Nov 5, 2003·Gastroenterology·Gregory WynnGeoffrey Burnstock
Feb 10, 2004·Histochemistry and Cell Biology·Zhenghua Xiang, Geoffrey Burnstock
Mar 31, 2004·British Journal of Pharmacology·James J Galligan
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H E RaybouldF L Christofi
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Peter Holzer
Jul 20, 2004·Histochemistry and Cell Biology·Zhenghua Xiang, Geoffrey Burnstock
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gregory WynnGeoffrey Burnstock
Nov 19, 2004·International Review of Cytology·Geoffrey Burnstock, Gillian E Knight
Nov 20, 2004·Cell and Tissue Research·Huai Zhen Ruan, Geoffrey Burnstock
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Jianhua Ren, James J Galligan
Feb 8, 2005·Neuropharmacology·Shinji FuruzonoYuji Imaizumi
Feb 19, 2005·The Journal of Physiology·J E MatosJ Leipziger
Aug 2, 2005·British Journal of Pharmacology·Esam GhanemJean-Marie Boeynaems

❮ Previous
Next ❯

Citations

Dec 1, 2009·Histochemistry and Cell Biology·Qiang YuZhenghua Xiang
Aug 2, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ran QiJie Chen
Aug 21, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Vic Velanovich
Jun 1, 2011·Current Gastroenterology Reports·Kirk A CaddellKeith Miller
Apr 10, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bindu P ChandrasekharanShanthi Srinivasan
Dec 31, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arun ChaudhuryRaj K Goyal
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Geoffrey Burnstock
Oct 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Leonie DurninVioleta N Mutafova-Yambolieva
Feb 22, 2012·The Journal of Physiology·Leonie DurninVioleta N Mutafova-Yambolieva
Jun 8, 2011·European Journal of Pharmacology·Annemie DeiterenJoris G De Man
Feb 8, 2011·European Journal of Pharmacology·Tatsuro NakamuraHiroshi Ozaki
Apr 11, 2009·Trends in Neurosciences·Alexander V GourineGeoffrey Burnstock
Oct 14, 2008·Pharmacology & Therapeutics·Luca AntonioliCorrado Blandizzi
Aug 30, 2008·Experimental Physiology·Geoffrey Burnstock
Apr 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P GomesP Vanden Berghe
Nov 13, 2009·British Journal of Pharmacology·Laura GrasaMarcel Jiménez
Sep 22, 2012·British Journal of Pharmacology·G FeiJ D Wood
May 19, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D GallegoM Jimenez
Jan 26, 2012·Neurourology and Urodynamics·E MengA F Brading
Oct 15, 2013·Annals of the New York Academy of Sciences·Annamaria AltomareDebora Compare
Jul 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L E PeriV N Mutafova-Yambolieva
Jul 12, 2011·The FEBS Journal·Leonie Durnin, Violeta N Mutafova-Yambolieva
Nov 5, 2011·International Journal of Experimental Pathology·Anna DomènechMarcel Jiménez
Jul 2, 2010·British Journal of Pharmacology·Joel R GeverAnthony P D W Ford
May 2, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexei Verkhratsky, Geoffrey Burnstock
Jan 1, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D GallegoM Jimenez
Dec 18, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Tamada, H Hashitani
Aug 14, 2009·Fundamental & Clinical Pharmacology·Nilce Mitiko Matsuda, Steven M Miller
Aug 19, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A E LomaxJ B Furness
Apr 10, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L DurninV N Mutafova-Yambolieva
Jul 8, 2014·European Journal of Pharmacology·Míriam Martínez-CutillasMarcel Jiménez
Jun 10, 2015·Autonomic Neuroscience : Basic & Clinical·Charles Kennedy
Jun 8, 2015·Autonomic Neuroscience : Basic & Clinical·Brian F King
Sep 27, 2013·The Keio Journal of Medicine·Geoffrey Burnstock
Jul 1, 2016·Therapeutic Innovation & Regulatory Science·Brenda CroweAndreas Brueckner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.