The kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity

Diabetes/metabolism Research and Reviews
J DamasP J Lefèbvre

Abstract

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert beneficial effects on insulin sensitivity and may reduce the occurrence of type 2 diabetes mellitus. One hypothesis explaining these effects of ACE inhibitors may relate to their capacity to interfere with bradykinin (BK) metabolism and action. BK may participate in the regulation of substrate utilization by several tissues by improving blood flow and substrate delivery to the tissues and also by promoting translocation of glucose transporters. Moreover, BK has been shown to increase phosphorylation of insulin receptor and its cell substrates. BK also appears to improve the release of insulin. Furthermore, insulin may activate the kallikrein-kinin system, which consequently may increase its metabolic effects. However, in experimental diabetes mellitus, BK can participate to the inflammatory reaction leading to Langerhans islets destruction. In diabetes, whereas tissue kallikrein mRNA levels were reduced in several organs, an overexpression of kinin receptors, an increase in plasma levels of kininogens and kallikrein and an activation of the kinin system have all been reporte...Continue Reading

Citations

Jun 20, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Paul Ernsberger, Richard J Koletsky
Dec 23, 2008·The Journal of Pharmacology and Experimental Therapeutics·Dale S EdgertonThomas R Strack
Jan 15, 2008·Peptides·Viviani Milan Ferreira RastelliZuleica Bruno Fortes
Apr 6, 2007·Peptides·Viviani Milan Ferreira RastelliZuleica Bruno Fortes
Jan 4, 2006·Diabetes/metabolism Research and Reviews·Licio A VellosoMario J A Saad
Nov 22, 2005·European Journal of Pharmacology·Jacques DamasPierre J Lefèbvre
Sep 27, 2014·PloS One·Lilia Maneva-RadichevaAlexei Y Savinov
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Sep 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dale S EdgertonAlan D Cherrington
May 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Marco A de Carvalho-FilhoMario José Abdalla Saad

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