PMID: 8461265Mar 1, 1993Paper

The Kallmann's syndrome variant (KSV) model of the schizophrenias

Schizophrenia Research
M A Cowen, M Green

Abstract

The KSV model of the schizophrenias proposes that up to 70% of schizophrenics have a pathogenic allele, or abnormal expression, of the KALIG-1 gene which is located at Xp22.3. This gene encodes a nerve-cell adhesion molecule (N-CAM) like protein, and is deleted in 66% of patients with Kallmann's syndrome, anosmia with secondary hypogonadism. Although superficially distinct, the schizophrenias and Kallmann's syndrome show numerous parallel trait defects which occur with a similar sex distribution. These defects are usually more profound in Kallmann's syndrome. Occasionally, Kallmann's patients exhibit additional defects, such as ichthyosis, which are due to the further deletion or translocation of adjacent genes. Since schizophrenics exhibit virtually all known trait defects in Kallmann's except these, it suggests that the aberrant genes are defective, but not deleted in schizophrenia. It also appears that compensatory mechanisms, involving serine proteases, are active in schizophrenia, which largely preserve fertility, but at the expense of an increased vulnerability to develop a psychosis by an episodic disruption of the blood-CSF barrier. Consequently, schizophrenia is rare in Kallmann's patients, while most schizophrenics ar...Continue Reading

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Citations

Jan 15, 1993·Biological Psychiatry·M A Cowen, M Green
Mar 17, 2000·Brain Research. Brain Research Reviews·D CopolovC Pantelis
Mar 2, 1999·American Journal of Medical Genetics·M O'NeillR Williamson
Apr 14, 2005·International Journal of Psychiatry in Medicine·George A VagenakisNeoklis A Georgopoulos
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·J H Lazarus
Aug 7, 2004·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Nebojsa Jović, Milka Drezgić

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