The kappa-opioid receptor antagonist nor-BNI inhibits cocaine and amphetamine, but not cannabinoid (WIN 52212-2), abstinence-induced withdrawal in planarians: an instance of 'pharmacologic congruence'.

Brain Research
Robert B RaffaScott M Rawls

Abstract

The broad applicability of receptor theory to diverse species, from invertebrates to mammals, provides evidence for the evolution in complexity of pharmacologic receptor diversification and of receptor-effector signal transduction mechanisms. However, pre-mammalian species have less receptor subtype differentiation, and thus, might share signal transduction pathways to a greater extent than do mammals, a phenomenon that we term 'pharmacologic congruence'. We have demonstrated previously that the lowest species considered to have a centralized nervous system, planarians, display both abstinence-induced and antagonist-precipitated withdrawal signs, indicative of the development of physical dependence. We report here: (1) amphetamine abstinence-induced withdrawal, and (2) the attenuation of cocaine and amphetamine, but not cannabinoid agonist (WIN 52212-2), abstinence-induced withdrawal by the opioid receptor antagonist naloxone and by the selective kappa-opioid receptor subtype antagonist nor-BNI (nor-Binaltorphimine), but not by the selective mu-opioid or the delta-opioid receptor subtype antagonists CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2)) and naltrindole. These results provide evidence that the withdrawal from cocaine ...Continue Reading

References

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Nov 8, 2001·European Journal of Pharmacology·R B Raffa, J M Valdez
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Sep 3, 2003·Neuroscience Letters·Robert B RaffaSumiyo Umeda
Jul 28, 2004·Brain Research·Sumiyo UmedaRobert B Raffa
Feb 1, 2005·Brain Research·Robert B Raffa, Prarthna Desai
Aug 18, 2006·Brain Research·Robert B RaffaRonald J Tallarida

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Citations

Aug 17, 2010·Journal of Pharmacological and Toxicological Methods·Chandni A VyasJonathan G Shackman
Jun 20, 2021·Physiology & Behavior·Sarah UddinScott M Rawls
Oct 2, 2009·Peptides·Richard J Bodnar

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