The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the Golgi.

The EMBO Journal
Monica GiannottaMichele Sallese

Abstract

Membrane trafficking involves large fluxes of cargo and membrane across separate compartments. These fluxes must be regulated by control systems to maintain homoeostasis. While control systems for other key functions such as protein folding or the cell cycle are well known, the mechanisms that control secretory transport are poorly understood. We have previously described a signalling circuit operating at the Golgi complex that regulates intra-Golgi trafficking and is initiated by the KDEL receptor (KDEL-R), a protein previously known to mediate protein recycling from the Golgi to the endoplasmic reticulum (ER). Here, we investigated the KDEL-R signalling mechanism. We show that the KDEL-R is predicted to fold like a G-protein-coupled receptor (GPCR), and that it binds and activates the heterotrimeric signalling G-protein Gα(q/11) which, in turn, regulates transport through the Golgi complex. These findings reveal an unexpected GPCR-like mode of action of the KDEL-R and shed light on a core molecular control mechanism of intra-Golgi traffic.

References

Dec 1, 1992·The Journal of Cell Biology·R SchwaningerW E Balch
Dec 5, 1993·Journal of Molecular Biology·A Sali, T L Blundell
Nov 1, 1996·The Journal of Biological Chemistry·D M BermanA G Gilman
Jan 7, 1998·The Journal of Cell Biology·A MironovA Luini
Jan 27, 1998·The Journal of Biological Chemistry·A A Scheel, H R Pelham
Jan 1, 1997·Annual Review of Cell and Developmental Biology·S M Thomas, J S Brugge
Oct 25, 2000·Protein Science : a Publication of the Protein Society·A FiserA Sali
Apr 17, 2001·Experimental Cell Research·E H PapK W Wirtz
Dec 13, 2002·Current Biology : CB·Arthur S Alberts
Apr 2, 2003·Cell Biology Education·Bruce Alberts, UNKNOWN National Academies
Jul 30, 2003·Biochemistry·Peter W DayPhilip B Wedegaertner
Nov 12, 2003·Life Sciences·C Harrison, J R Traynor
Jan 28, 2004·Cell·Juan S Bonifacino, Benjamin S Glick
Jan 20, 2005·The Journal of Cell Biology·Reinhart Heinrich, Tom A Rapoport
May 10, 2005·Nature Cell Biology·Matteo BonazziAlberto Luini
Sep 27, 2005·Cellular Signalling·Katherine B Hubbard, John R Hepler
Jun 10, 2006·The EMBO Journal·Michele SalleseAlberto Luini
Apr 13, 2007·Acta Physiologica·R J Lefkowitz
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Sep 21, 2007·Molecular Biology of the Cell·Jorge CancinoAlfonso González
Dec 19, 2007·The Journal of Cell Biology·Irina RaykhelLloyd Ruddock
Jul 22, 2008·Nature Cell Biology·Teodoro PulvirentiAlberto Luini
May 19, 2009·Seminars in Cell & Developmental Biology·Michele SalleseAlberto Luini
Jul 1, 2009·Experimental Cell Research·Maria Grazia CattaneoLucia M Vicentini
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shaun G WellerMark A McNiven
Apr 28, 2010·Experimental Cell Research·Massimo MicaroniAlexander A Mironov

❮ Previous
Next ❯

Citations

Jul 4, 2013·Histochemistry and Cell Biology·Kerstin D TillmannHesso Farhan
Jul 4, 2013·Histochemistry and Cell Biology·Carolyn E Machamer
Jul 23, 2013·Histochemistry and Cell Biology·Jorge CancinoAlberto Luini
Nov 10, 2013·PloS One·Elliott W AbramsDeborah J Andrew
Jan 3, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Christiane TrößeSussie Dalvin
Oct 9, 2014·Nature Communications·Michael A GorenAnant K Menon
Dec 25, 2015·ELife·Ramanath Narayana HegdeAlberto Luini
Feb 3, 2016·Trends in Cell Biology·Frederic Bard, Joanne Chia
Nov 2, 2013·Biology of the Cell·A Soledad CoriaAlberto M Díaz Añel
Apr 24, 2015·Molecular Biology of the Cell·Valentina MillarteHesso Farhan
Jun 13, 2015·BioMed Research International·Monica GiannottaMichele Sallese
Mar 26, 2015·Frontiers in Pharmacology·Sabrina M de MunnikHenry F Vischer
Jun 1, 2016·Nature Communications·Maria Luisa BarrettaAntonino Colanzi
Aug 6, 2016·Scientific Reports·Björn BeckerManfred J Schmitt
Apr 1, 2014·Current Opinion in Cell Biology·Roshanak Irannejad, Mark von Zastrow
Oct 7, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Prajakta Gosavi, Paul A Gleeson
Aug 5, 2014·Nature Communications·Stéphanie RosciglioneChristine Lavoie
Jun 1, 2018·Molecular Biology of the Cell·Yevgeniy V SerebrenikCraig M Crews
Feb 18, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nicolas AznarPradipta Ghosh
Aug 16, 2018·Annual Review of Cell and Developmental Biology·Christina SchoenherrAdam Byron
Oct 20, 2012·Traffic·Jorge Cancino, Alberto Luini
Jul 26, 2019·Cellular and Molecular Neurobiology·Zhangyuan LiaoWenliang Li
Aug 6, 2019·FEBS Letters·Prajakta Kulkarni-GosaviPaul A Gleeson
Aug 10, 2019·FEBS Letters·Rosaria Di MartinoAlberto Luini
Jun 25, 2020·Journal of Cell Science·Francesca Patella, Daniel F Cutler
Sep 12, 2015·Oncotarget·Ming Yuan LiPei Gang Wang
Jan 24, 2018·Journal of Cell Science·Prajakta GosaviPaul A Gleeson
Jul 3, 2019·Frontiers in Cell and Developmental Biology·Sakari Kellokumpu
Jul 25, 2019·Scientific Reports·Andrea BlumManfred J Schmitt
Nov 14, 2019·International Journal of Molecular Sciences·Hiroshi KokubunTomohiko Aoe
Aug 12, 2017·Biology of the Cell·Inmaculada Ayala, Antonino Colanzi
Sep 3, 2018·Histochemistry and Cell Biology·Jaakko Saraste, Michaël Marie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.