The key role of the level of ACE2 gene expression in SARS-CoV-2 infection.

Aging
Yves Lecarpentier, Alexandre Vallée

Abstract

SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. In circumstances in which the ACE2 level is low, the incidence of Covid-19 seems to be fewer. Two clinical patterns illustrate this observation, i. e., in infants and in Alzheimer's disease (AD). Very young children and AD patients get little COVID-19, in part probably due to decreased expression of ACE2. The determination of the nasal level of ACE2 gene expression could provide a useful scale to predict the susceptibility to contract the SARS-CoV-2 infection.

References

May 29, 2004·Trends in Pharmacological Sciences·Anthony J TurnerNigel M Hooper
Jan 13, 2012·Neuro-degenerative Diseases·Laura MateosAngel Cedazo-Mínguez
Feb 26, 2016·Current Neurovascular Research·Teng JiangYing-Dong Zhang
Jul 20, 2017·Npj Aging and Mechanisms of Disease·Xiao-Li WangMasatsugu Horiuchi
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
May 29, 2018·Clinical Science·Mariela M GironacciMauro G Silva
Jan 22, 2019·Journal of Alzheimer's Disease : JAD·John W Wright, Joseph W Harding
Feb 3, 2019·The Journal of Pharmacology and Experimental Therapeutics·Meredith HayJohn P Konhilas
Mar 15, 2020·The Lancet. Respiratory Medicine·Lei FangMichael Roth
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing YangYongning Zhou
Mar 18, 2020·Pediatrics·Yuanyuan DongShilu Tong
May 21, 2020·JAMA : the Journal of the American Medical Association·Supinda BunyavanichAlfin Vicencio
May 21, 2020·JAMA : the Journal of the American Medical Association·Ankit B Patel, Ashish Verma
Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Jingwen LiNian Xiong
Jan 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Murat Oz, Dietrich Ernst Lorke

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Citations

Oct 13, 2021·Expert Opinion on Pharmacotherapy·Fabio AngeliGianpaolo Reboldi

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