PMID: 1628651Jul 1, 1992

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane

European Journal of Biochemistry
J HuwylerJ Gut

Abstract

Hydrochlorofluorocarbons (HCFCs) have been identified as chemical replacements of the widely used chlorofluorocarbons (CFCs) that are implicated in stratospheric ozone depletion. Many HCFCs are structural analogues of the anesthetic agent halothane and may follow a common pathway of biotransformation and formation of adducts to protein-centered and other cellular nucleophiles. Exposure of rats to a single dose of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) or of the candidate CFC substitute HCFC 123 (2,2-dichloro-1,1,1-trifluoroethane) led to the formation of trifluoroacetylated protein adducts (CF3CO-proteins) not only in the liver, but also in the kidney as a novel target tissue for protein trifluoroacetylation. CF3CO-proteins in the kidney amounted to about 5% of those formed in the liver of the same animal. The amount of CF3CO-proteins formed within the kidney was roughly reflected by the capacity of metabolism of halothane or HCFC 123 by rat kidney microsomes in vitro which amounted to about 10% of that observed with liver microsomes. By immunohistochemistry, CF3CO-proteins in the kidney were mainly localized in the tubular segments of the cortex. In the liver, the density of CF3CO-proteins decreased from the centra...Continue Reading

References

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Citations

Jan 1, 1993·Pharmacology & Therapeutics·J GutJ Huwyler
Jun 16, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A ZanovelloM Manno
Apr 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R TolandoM Manno
Jan 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G D LoizouM W Anders
Nov 27, 2018·Critical Reviews in Toxicology·George M Rusch
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H R Amouzadeh, L R Pohl
Mar 6, 2018·Frontiers in Immunology·Urs Christen, Edith Hintermann

Related Concepts

FC-123
Cell Fractionation
Chlorofluorocarbons, Methane
Narcotan
Hydrocarbons, Halogenated
Kidney
Liver
Microsomes
Microsomes, Liver
Luminal

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