The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice

Oxidative Medicine and Cellular Longevity
Yining ZhangFasheng Li

Abstract

PM2.5 is well known as a major environmental pollutant; it has been proved to be associated with kidney diseases. The kidney damage involves oxidative stress and/or inflammatory response. NOX4 is a major source of reactive oxygen species (ROS) generation in the kidney, and the excessive generation of ROS is recognized to be responsible for oxidative stress. To elucidate whether short-term PM2.5 exposure could induce kidney damage, we exposed BALB/c mice to PM2.5 intratracheally and measured the biomarkers of kidney injury (KIM-1, cystatin C), oxidative stress (MDA, SOD-1, and HO-1), and inflammatory response (NF-κB, TNF-α). Acute kidney damage and excessive oxidative stress as well as transient inflammatory response were observed after PM2.5 installation. The overexpression of some components of the angiotensin system (RAS) after PM2.5 exposure illustrated that RAS may be involved in PM2.5-induced acute kidney injury. CEOs (compound essential oils) have been widely used because of their antioxidant and anti-inflammation properties. Treatment with CEOs substantially attenuated PM2.5-induced acute kidney injury. The suppression of RAS activation was significant and earlier than the decrease of oxidative stress and inflammatory re...Continue Reading

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Citations

Jul 21, 2020·Environmental Pollution·Miao LiuXiaomin Zhang
Apr 2, 2021·Reviews on Environmental Health·Liwei YangLin Ye
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Jingbin XuFasheng Li
Apr 21, 2021·Journal of Agricultural and Food Chemistry·Xueyan WuGuang Yang
Dec 5, 2018·Environmental Science & Technology·Avinash Kumar AgarwalBushra Ateeq

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Methods Mentioned

BETA
MDA
protein assay
electrophoresis

Software Mentioned

GraphPad
GraphPad Prism

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