The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Steven W M Olde DaminkPeter B Soeters

Abstract

Upper gastrointestinal (UGI) bleeding in cirrhosis is associated with enhanced ammoniagenesis, the site of which is thought to be the colon. The aims of this study were to evaluate interorgan metabolism of ammonia following an UGI bleed in patients with cirrhosis. Study 1: UGI bleed was simulated in 8 patients with cirrhosis and a transjugular intrahepatic portasystemic stent-shunt (TIPSS) by intragastric infusion of an amino acid solution that mimics the hemoglobin molecule. We sampled blood from the femoral artery and a femoral, renal, portal, and hepatic vein for 4 hours during the simulated bleed and measured plasma flows across these organs. Study 2: In 9 cirrhotic patients with an acute UGI bleed that underwent TIPSS insertion, blood was sampled from an artery and a hepatic, renal, and portal vein, and plasma flows were measured. Study 1: During the simulated bleed, arterial concentrations of ammonia increased significantly (P =.002). There was no change in ammonia production from the portal drained viscera, but renal ammonia production increased 6-fold (P =.008). In contrast to an unchanged ammonia removal by the liver, a significant increase in muscle ammonia removal was observed. Study 2: In patients with an acute UGI ...Continue Reading

References

Mar 1, 1979·The Journal of Clinical Investigation·A H LockwoodF Plum
Jul 1, 1990·Physiological Reviews·A J MeijerR A Chamuleau
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S GaianiL Barbara
Apr 1, 1987·Physiological Reviews·A J Cooper, F Plum
Apr 1, 1967·The Journal of Clinical Investigation·R F Pitts, W J Stone
Mar 1, 1984·The Journal of Clinical Investigation·D W Good, M B Burg
Jul 1, 1981·The Journal of Clinical Investigation·O E OwenG Boden
Dec 1, 1993·The Journal of Clinical Investigation·C H DejongP B Soeters
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FabbriE Pisi
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F DebatinW A Fuchs
Aug 1, 1996·Seminars in Liver Disease·R F Butterworth
Mar 1, 1996·Journal of Vascular and Interventional Radiology : JVIR·E M WalserA R Siddiqui
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S Basile, E A Jones
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J O ClemmesenP Ott
Sep 17, 1999·Journal of Hepatology·C F WeltersP B Soeters
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Feb 1, 1961·The Journal of Clinical Investigation·E E OWENM P TYOR
Feb 1, 1963·The American Journal of Physiology·R F PITTSJ KLEIN
Feb 1, 1960·The Journal of Clinical Investigation·E E OWENJ N BERRY

❮ Previous
Next ❯

Citations

Feb 1, 2005·Lancet·Debbie Shawcross, Rajiv Jalan
Nov 20, 2010·Pediatric Emergency Care·Nermeen M GalalMabroka Dabnon
Nov 17, 2007·Journal of Gastroenterology and Hepatology·Peter SörösManfred J Müller
Jul 10, 2004·BMJ : British Medical Journal·Debbie L Shawcross, Rajiv Jalan
Jul 16, 2010·World Journal of Gastroenterology : WJG·Amit S SeyanDebbie L Shawcross
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Evangelos Kalaitzakis, Einar Björnsson
Aug 21, 2013·Hospital Practice·Kristina R Chacko, Samuel H Sigal
Mar 5, 2013·Scandinavian Journal of Gastroenterology·Evangelos KalaitzakisEinar Björnsson
Nov 19, 2013·Expert Review of Gastroenterology & Hepatology·Jonathan P Sturgeon, Debbie L Shawcross
Oct 16, 2007·Chest·Alison S Clay, Bryan E Hainline
Dec 27, 2015·Journal of the American College of Surgeons·Motaz QadanBrendan C Visser
Jan 16, 2007·Best Practice & Research. Clinical Gastroenterology·Gavin Wright, Rajiv Jalan
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars Marius YtrebøChristopher F Rose
May 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A DaviesRajiv Jalan
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elwyn Elias
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven W M Olde DaminkPeter B Soeters
Jul 24, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Maartje A J van den BroekFuat H Saner
Feb 3, 2009·Alimentary Pharmacology & Therapeutics·S W M Olde DaminkR Jalan
Aug 3, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Gavin WrightRajiv Jalan
Dec 14, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Gavin WrightRajiv Jalan
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Liliane MpabanziSteven W M Olde Damink
Aug 12, 2014·Journal of Hepatology·Vishwadeep AhluwaliaJasmohan S Bajaj
Apr 22, 2015·Advanced Drug Delivery Reviews·Simon Matoori, Jean-Christophe Leroux
Jul 22, 2015·Clinics in Liver Disease·Catherine Lucero, Elizabeth C Verna
May 11, 2010·Journal of Hepatology·Gavin WrightRajiv Jalan
May 14, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I David Weiner
Apr 14, 2015·Mayo Clinic Proceedings·Elliot B TapperVilas R Patwardhan
Nov 3, 2016·Therapeutic Advances in Gastroenterology·Meritxell Ventura-CotsJuan Córdoba
Jun 29, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rajagopal ChadalavadaKevin Mullen
May 25, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gavin WrightRajiv Jalan
Sep 5, 2009·European Journal of Gastroenterology & Hepatology·Mariano MalaguarneraFabio Galvano
Feb 1, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases· ShalimarRajiv Jalan
Feb 4, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven W M Olde DaminkRajiv Jalan
Jun 20, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lars M YtrebøNicolaas E P Deutz
Aug 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·I David WeinerJeff M Sands
Aug 25, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marcel C G van de PollCornelis H C Dejong
Aug 16, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marcel C G van de PollCornelis H C Dejong
May 8, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·D L ShawcrossR Jalan
Dec 25, 2016·Metabolic Brain Disease·Srinivasan DasarathyChristopher F Rose

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Steven W M Olde DaminkRajiv Jalan
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Sherzad BalataRajiv Jalan
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Steven W M Olde DaminkPeter B Soeters
American Journal of Physiology. Gastrointestinal and Liver Physiology
Lars M YtrebøNicolaas E P Deutz
© 2022 Meta ULC. All rights reserved