The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress

Cell Death & Disease
Liang TaoDan Weng

Abstract

Endoplasmic reticulum (ER) stress contributes to the development and progression of many chronic inflammatory diseases, including type 2 diabetes, obesity, atherosclerosis, neurodegenerative diseases, and cancer. ER stress has been reported to induce inflammasome activation and release of mature IL-1β, which contributes to many inflammatory diseases. The molecular mechanisms that activate the inflammasome during ER stress are still poorly understood. Here we report that the kinase receptor-interacting protein 1 (RIP1) plays an important role in ER stress-induced activation of inflammasome. Inhibition of RIP1 kinase activity by Necrostatin-1 or siRNA-mediated RIP1 knockdown significantly reduced ER stress-induced caspase-1 cleavage and IL-1β secretion in both bone marrow-derived macrophages (BMDMs) and J774A.1 macrophages. We speculate that the mitochondria fission factor dynamin-related protein 1 (DRP1) and reactive oxygen species (ROS) might function as the effectors downstream of RIP1 to mediate inflammasome activation. Our study reveals a critical role for RIP1 in regulating ER stress-induced inflammation responses, and proposes RIP1 as a potential pharmaceutical target to treat diseases resulting from unresolved ER stress-r...Continue Reading

References

Mar 1, 1992·The Journal of Cell Biology·R D KlausnerJ Lippincott-Schwartz
Feb 20, 2010·Nature Reviews. Immunology·Jurg Tschopp, Kate Schroder
Mar 5, 2010·European Journal of Immunology·Fabio Martinon
Jan 27, 2012·Cell Death & Disease·P MenuJ Tschopp
Jul 31, 2012·Immunity·Gregory I VladimerEgil Lien
Dec 25, 2012·Immunity·Tae-Bong KangDavid Wallach
Jan 16, 2013·Current Opinion in Microbiology·Gregory I VladimerEgil Lien
Feb 8, 2013·Cold Spring Harbor Perspectives in Biology·Brooke M GardnerPeter Walter
Aug 31, 2013·Nature Reviews. Drug Discovery·Claudio HetzHeather P Harding
Oct 2, 2013·Annual Review of Physiology·Dana E ChristoffersonJunying Yuan
Dec 11, 2013·The Journal of Biological Chemistry·Jaemin Lee, Umut Ozcan
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin ShenderovAlan Sher
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dan WengEgil Lien
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Naomi H PhilipIgor E Brodsky
Nov 12, 2014·Annual Review of Pathology·Scott A Oakes, Feroz R Papa
Nov 15, 2014·Nature Immunology·Manira Rayamajhi, Edward A Miao
Feb 11, 2015·Trends in Cell Biology·Kim Newton
Jun 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lily DaraNeil Kaplowitz
Jul 24, 2015·Journal of Cellular Physiology·Stewart Siyan CaoLynn Shi
Sep 12, 2015·Cell Death & Disease·C LebeaupinB Bailly-Maitre
Apr 3, 2016·Immunity·Moritz M GaidtVeit Hornung
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Kenta Moriwaki, Francis Ka-Ming Chan
Jun 28, 2016·Nature Reviews. Immunology·Joep GrootjansRichard S Blumberg
Dec 16, 2016·International Journal of Molecular Sciences·Zhongxin ZhouZhongming Zhang
Jan 19, 2017·International Journal of Molecular Sciences·Chenxia HuLanjuan Li
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ozlem TufanliEbru Erbay

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Citations

Jun 15, 2019·Nature Reviews. Rheumatology·Insoo Kang, Richard Bucala
Apr 2, 2020·Infection and Immunity·Sharon K Kuss-Duerkop, A Marijke Keestra-Gounder
Sep 13, 2019·Cells·Kwang-Ho Lee, Tae-Bong Kang
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Shengjie YangSongzi Wang
Mar 5, 2021·Toxicology·Gopalapura J VishalakshiKesturu S Girish
May 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ivo Ricardo de Seabra Rodrigues DiasLiang Liu
Jul 30, 2021·Free Radical Biology & Medicine·Yuguo YiDan Weng

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Methods Mentioned

BETA
protein folding
ELISA
confocal microscopy
flow cytometry
transfection
Confocal
GTPase
PCR

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