The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation

The Journal of Biological Chemistry
Elizabeth A DuncanAlbert S Baldwin

Abstract

Phosphorylation of histone H3 protein at serine 10 is an important step in chromatin remodeling during transcriptional transactivation. IkappaB kinase-alpha (IKK-alpha) and Mitogen- and Stress-activated protein Kinases 1 and 2 (MSK1/2) have been shown to play key roles in the transcriptional regulation of immediate early genes such as c-fos. Interestingly, IKK-alpha and MSK1/2 have also been implicated as histone H3-Ser10 kinases. In this work, we have shown that MSK1/2 are required for epidermal growth factor (EGF)-induced, but not tumor necrosis factor-induced, histone H3-Ser10 phosphorylation, both globally and at specific promoters. Consistent with this, MSK1/2 are required for optimal immediate early c-fos transcription in response to EGF potentially through control of both H3-Ser10 and promoter-associated cAMP-response element-binding protein phosphorylation. Furthermore, MSK1/2 control EGF-induced IkappaB alpha promoter H3-Ser10 phosphorylation in the absence of elevated transcription. These studies demonstrate the existence of pathway-specific mechanisms to control histone H3-Ser10 phosphorylation and gene expression.

References

Jan 1, 1997·Annual Review of Biochemistry·M Montminy
Jan 19, 2000·Nature·B D Strahl, C D Allis
May 2, 2002·Cell·Sankar Ghosh, Michael Karin
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xinmin ZhangMarc Montminy

❮ Previous
Next ❯

Citations

Oct 16, 2012·Journal of Molecular Neuroscience : MN·Bo NingQi Pang
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
Nov 7, 2007·Nature Structural & Molecular Biology·Sean D TavernaDinshaw J Patel
Oct 19, 2011·Molecular and Cellular Biology·Taraswi Banerjee, Debabrata Chakravarti
Nov 10, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Beatriz Pérez-CadahíaJames R Davie
Nov 21, 2008·American Journal of Physiology. Cell Physiology·Corttrell M KinneyPaul E DiCorleto
Feb 2, 2008·American Journal of Respiratory Cell and Molecular Biology·Se-Ran YangIrfan Rahman
Jul 12, 2008·Molecular & Cellular Proteomics : MCP·Marta Sanz-GarcíaPedro A Lazo
Jun 13, 2013·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Michela Garofalo, Carlo M Croce
May 26, 2009·Trends in Biochemical Sciences·Linda VermeulenGuy Haegeman
Jun 23, 2009·Biochemical and Biophysical Research Communications·Shoichiro TangeMichinari Hamaguchi
Jan 19, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shannon HealyJames R Davie
Jun 10, 2006·The Journal of Biological Chemistry·Padma Kannan-ThulasiramanLeonidas C Platanias
Apr 29, 2020·Annual Review of Vision Science·Manuela LahnePeter F Hitchcock
May 30, 2020·International Journal of Molecular Sciences·Vidhya A NairWael M Abdel-Rahman

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.