The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.

Proceedings of the National Academy of Sciences of the United States of America
B I LordT M Dexter

Abstract

Cell proliferation in the bone marrow and blood of two patients with metastatic breast cancer who were treated with granulocyte colony-stimulating factor was studied by using [3H]thymidine labeling and autoradiography. Additionally, the fate of neutrophils labeled with 99mTc-hexamethylpropyleneamineoxime was observed following granulocyte colony-stimulating factor infusion. Proliferation increased in all stages of granulopoiesis, but a significant amount of the increased production stemmed from a greater input to the myeloblast compartment. Changes in the myelogram combined with the increased labeling indicated a faster throughput of cells, which resulted in labeled cells appearing in the circulation within 1 day compared to the normal 4 or 5 days. The 99mTc studies demonstrated no sequestration of circulating neutrophils by spleen, lungs, or liver. The half-life of the circulating neutrophils was not significantly changed, and calculations from the flow of labeled cells to the peripheral blood indicated an increase of 3.2 extra amplification divisions during neutrophil development. The dramatic neutrophil response to granulocyte colony-stimulating factor can therefore be accommodated by a relatively modest increase in granulop...Continue Reading

References

Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A M CohenL M Souza
Mar 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·D R BoggsM M Wintrobe

❮ Previous
Next ❯

Citations

Oct 24, 2002·Bulletin of Mathematical Biology·Eliezer ShochatLee Segel
Jan 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Offner
Dec 23, 2004·Journal of Mathematical Biology·M ScholzM Loeffler
Mar 5, 2008·Journal of Mathematical Biology·Catherine Foley, Michael C Mackey
Sep 6, 2005·Bulletin of Experimental Biology and Medicine·E D GoldbergT Yu Khrichkova
Jun 27, 2013·Pharmaceutical Research·Mélanie L PastorDidier Concordet
Jun 8, 2007·Bulletin of Mathematical Biology·E ShochatL A Segel
Oct 12, 2012·Clinical Pharmacokinetics·Mario González-SalesJuan Jose Pérez-Ruixo
Jul 1, 1994·Immunopharmacology·M A Jagels, T E Hugli
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Sanchiz, A Milla
Jan 9, 2009·Cell Stem Cell·Simon C PitchfordSara M Rankin
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H StögerC C Zielinski
Sep 25, 2002·Critical Reviews in Oncology/hematology·Louis M PelusAndrew G King
Jun 30, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M AfzalM Frieri
Oct 25, 2011·Cellular & Molecular Immunology·Ende ZhaoWeiping Zou
Jun 10, 2000·British Journal of Haematology·Y EbiharaK Tsuji
Jul 2, 1992·The New England Journal of Medicine·G J Lieschke, A W Burgess
May 6, 2009·The Journal of Experimental Medicine·Kuang-Hsiang ChuangChawnshang Chang
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·B D Walker
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·M Foote, W Welch
Dec 20, 1999·Journal of Hematotherapy & Stem Cell Research·W Welch, M Foote
Nov 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P BallarinoI Pannacciulli
Nov 30, 2006·Current Opinion in Hematology·Matthew J Christopher, Daniel C Link
Nov 12, 2005·Journal of Pediatric Hematology/oncology·Esther M te PoeleEvelina S J M de Bont
Nov 9, 2007·Current Opinion in Allergy and Clinical Immunology·Alejandro A Schäffer, Christoph Klein
Jul 1, 1990·British Journal of Haematology·G Morstyn
Jul 1, 1994·British Journal of Haematology·T W HuizingaA E von dem Borne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.