PMID: 12774932May 31, 2003Paper

The kinetics of immune reconstitution after cord blood transplantation and selected CD34+ stem cell transplantation in children: comparison with bone marrow transplantation

International Journal of Hematology
Hiroyasu InoueShunichi Kato

Abstract

The present study compares immune reconstitution after allogeneic cord blood transplantation (CBT) and CD34+ stem cell transplantation (CD34-SCT) with that after bone marrow transplantation (BMT). Eighty-eight children who underwent CBT (20 patients), BMT (58), and CD34-SCT (10) were enrolled, and lymphocytes and T-, B-, and natural killer-lymphocyte subsets were monitored for more than 5 years after transplantation. CBT recipients showed significant ircreases in (1) total lymphocyte counts (P < .001), (2) CD4+/CD8+ cell ratios (P < .01), (3) CD4+ and CD4+CD45RA+ cells (P < .001), (4) CD8+CD11b+ cells (P < .001), and (5) CD19+ and CD19+CD5+ cells (P < .0001) and marked decreases in the frequencies of CD8+ and CD8+CD11b- cells (P < .0001). CD34-SCT recipients showed lower lymphocyte counts in the first 6 months and an emergence of lymphocyte and CD4+CD45RA+ cells at approximately 9 months and 1 year. Both CBT and CD34-SCT recipients showed increased frequencies of CD56+ cells at 1 month (CD34-SCT versus BMT, P < .001) but decreased frequencies after 6 months (CBT versus BMT, P < .001). Lymphoproliferative responses to exogenous interleukin 2 were constantly lower in CBT and CD34-SCT recipients than in BMT recipients. These resul...Continue Reading

References

Jan 1, 1989·Advances in Immunology·T J Kipps
Mar 4, 1993·The New England Journal of Medicine·N A KernanJ McCullough
Jul 18, 1996·The New England Journal of Medicine·J KurtzbergP Rubinstein
Jun 1, 1997·Immunological Reviews·R Parkman, K I Weinberg
Aug 8, 1998·International Journal of Hematology·S KatoT Inamitsu
Mar 29, 2001·Experimental Hematology·A MorettaF Locatelli

❮ Previous
Next ❯

Citations

Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo MartinoUNKNOWN Infectious Disease Working Party of the European Group for Blood and Marrow Transplantation
Jan 16, 2008·Expert Opinion on Biological Therapy·Andrew R Rezvani, Rainer Storb
Sep 27, 2006·Clinical and Laboratory Haematology·Y ShonoM Imamura
Sep 6, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Coco de KoningStefan Nierkens
Apr 9, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Julia A Brown, Vassiliki A Boussiotis
Mar 1, 2008·British Journal of Haematology·Fernando O Pinto, Irene Roberts
Apr 7, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A RuggeriV Rocha
Dec 3, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E AbediM J Ashraf
Aug 14, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Benjamin R OshrineNancy Bunin
Aug 6, 2005·Cytotherapy·W Tse, Mj Laughlin
Nov 15, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pau MontesinosGuillermo F Sanz
Mar 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William Ying Khee HwangYeh Ching Linn
Feb 5, 2008·Pediatric Clinics of North America·Soonie R PatelPaul T Heath
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasmin Khan ParrishKimberly J Payne
Mar 1, 2019·Open Forum Infectious Diseases·Kathleen A LinderMarisa H Miceli
May 26, 2018·Bone Marrow Transplantation·Kathleen A LinderMarisa H Miceli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.