The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus

Virus Research
Kazuya ShiratoIkuo Takashima

Abstract

The envelope (E) protein glycosylation status of the New York strain of West Nile (WN) virus is an important determinant of virus neuroinvasiveness. To elucidate the determinant of the difference between E protein-glycosylated and non-glycosylated WN virus infections, the cytokine expression of murine peritoneal macrophages infected with each virus was examined. Tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta were up-regulated with replication of the E protein-glycosylated virus. Interferon (IFN) beta and IL-6 were up-regulated with the clearance of both viruses. These results suggest that TNFalpha and IL-1beta expression are related to the virulence of E protein-glycosylated WN virus.

References

Feb 4, 1994·Brain Research·R J HaririJ B Ghajar
Feb 26, 2000·The Journal of Investigative Dermatology·L J JohnstonN J King
Aug 9, 2003·Microbiology and Immunology·Kazuya ShiratoIkuo Takashima
Jun 10, 2004·Antiviral Chemistry & Chemotherapy·John D MorreyRobert W Sidwell
Sep 16, 2004·Journal of Medical Virology·Kazuya ShiratoIkuo Takashima
Jan 18, 2006·Journal of Virology·Carl W DavisTheodore C Pierson

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Citations

Jun 15, 2014·Brain Research·Amir H SabouriNora E Sarvetnick
May 30, 2008·Journal of Virology·Kok-Fai KongRuth R Montgomery
Jan 1, 2009·Journal of Innate Immunity·Kristin M Rogers, Mark Heise
Jul 28, 2011·Cellular Microbiology·Alvaro ArjonaErol Fikrig
Feb 4, 2010·Journal of Neuroscience Research·Swarupa ChakrabortyAnirban Basu
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alvaro ArjonaErol Fikrig

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