PMID: 9188733Jun 1, 1997Paper

The kinetics of protein-protein recognition

Proteins
J Janin

Abstract

We examine a simple kinetic model for association that incorporates the basic features of protein-protein recognition within the rigid body approximation, that is, when no large conformation change occurs. Association starts with random collision at the rate k(coll) predicted by the Einstein-Smoluchowski equation. This creates an encounter pair that can evolve into a stable complex if and only if the two molecules are correctly oriented and positioned, which has a probability p(r). In the absence of long-range interactions, the bimolecular rate of association is p(r) k(coll). Long-range electrostatic interactions affect both k(coll) and p(r). The collision rate is multiplied by q(t), a factor larger than 1 when the molecules carry net charges of opposite sign as coulombic attraction makes collisions more frequent, and less than 1 in the opposite case. The probability p(r) is multiplied by a factor q(r) that represents the steering effect of electric dipoles, which preorient the molecules before they collide. The model is applied to experimental data obtained by Schreiber and Fersht (Nat. Struct. Biol. 3:427-431, 1996) on the kinetics of barnase-barstar association. When long-range electrostatic interactions are fully screened o...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S H Northrup, H P Erickson
Jan 1, 1991·Proteins·J CherfilsJ Janin
Nov 1, 1989·Trends in Biochemical Sciences·R W Hartley
Oct 1, 1989·Protein Engineering·A V Finkelstein, J Janin
Jan 1, 1985·Annual Review of Biophysics and Biophysical Chemistry·O G Berg, P H von Hippel
Mar 1, 1985·Biopolymers·J Janin, S J Wodak
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M I Page, W P Jencks
May 13, 1982·Nature·Y MauguenA Jack
Jan 1, 1995·Proteins·J Janin
May 1, 1996·Nature Structural Biology·G Schreiber, A R Fersht
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Jucovic, R W Hartley
Jan 1, 1995·Progress in Biophysics and Molecular Biology·J Janin

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Citations

Oct 29, 2014·The Journal of Physical Chemistry. B·Mauro LapelosaIsidro E Zarraga
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·C J Camacho, S Vajda
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·D ReichmannG Schreiber
Oct 7, 1998·Protein Science : a Publication of the Protein Society·M G TaylorJ F Kirsch
Mar 9, 2007·The Journal of Biological Chemistry·Alice KearneyP Anton van der Merwe
Feb 7, 2009·Chemical Reviews·G SchreiberH-X Zhou
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·James R HornAnthony A Kossiakoff
Mar 4, 2011·The Journal of Physical Chemistry. B·Pavel SrbRichard Hrabal
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xin ZhangShu-ou Shan
Nov 10, 2001·Annual Review of Biomedical Engineering·C M Roth, M L Yarmush
Feb 18, 2005·Nature Immunology·Michelle Krogsgaard, Mark M Davis
Oct 1, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David BanDonghan Lee
Nov 22, 2000·The Journal of Cell Biology·K S ThornR D Vale
Dec 31, 2015·Biochemistry·Daisuke SatoMasamichi Ikeguchi
Sep 5, 2002·Proteins·Carlos Adriel Del Carpio-MuñozToshikazu Yoshikawa
Jul 18, 2015·Protein Science : a Publication of the Protein Society·Min-Yeh TsaiPeter G Wolynes
Jul 24, 2007·Biochimica Et Biophysica Acta·Hugo NájeraD Alejandro Fernández-Velasco
Apr 17, 2007·Journal of Molecular Biology·Li ZhangDimitrios Morikis
Jul 2, 2004·Proteins·Minoru Kubo, Etsuro Ito
May 11, 2004·Protein Science : a Publication of the Protein Society·Maximilian Schlosshauer, David Baker
Apr 21, 2004·Protein Science : a Publication of the Protein Society·Douglas D Banks, Lisa M Gloss
Feb 26, 2003·Biopolymers·Garegin A Papoian, Peter G Wolynes
Mar 13, 2003·European Journal of Biochemistry·Victoria I Bunik
Aug 10, 2006·Journal of Molecular Recognition : JMR·Donald J Winzor, Craig M Jackson
May 23, 2008·Journal of Molecular Recognition : JMR·Kathryn M ArmstrongBrian M Baker
Apr 13, 2011·Biotechnology Progress·Chris A KieslichDimitrios Gunopulos
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Piotr SetnyJoachim Dzubiella
Apr 15, 2010·Chembiochem : a European Journal of Chemical Biology·Yanyan LiRolf Müller
May 20, 2009·Biophysical Journal·Michal HarelGideon Schreiber
Jul 17, 2015·Proteins·Madhurima Das, Gautam Basu
Jan 27, 2005·Journal of Molecular Biology·Rebecca L Davis-HarrisonBrian M Baker
Feb 14, 2006·Biophysical Journal·Martin HembergMauricio Barahona

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